Pozelimab Biosimilar – Anti-C5 mAb – Research Grade

Description of Pozelimab Biosimilar - Anti-C5 mAb - Research Grade

Introduction

Pozelimab Biosimilar, also known as Anti-C5 mAb, is a research grade monoclonal antibody that targets the complement component 5 (C5) protein. This innovative therapeutic agent has shown promising results in various preclinical studies and is being developed as a potential treatment for a range of autoimmune and inflammatory diseases.

Structure of Pozelimab Biosimilar

Pozelimab Biosimilar is a fully humanized monoclonal antibody, meaning that it is derived from human cells and has a high degree of specificity and affinity for its target. The antibody is composed of two heavy chains and two light chains, which are connected by disulfide bonds. It has a molecular weight of approximately 150 kDa and belongs to the IgG1 subclass.

Mechanism of Action

Pozelimab Biosimilar works by binding to the complement component 5 (C5) protein, which is a key component of the complement system. This system is an essential part of the body’s immune defense, but when overactivated, it can lead to tissue damage and inflammation. By binding to C5, Pozelimab Biosimilar prevents its cleavage into C5a and C5b, which are potent pro-inflammatory molecules. This, in turn, inhibits the downstream activation of the complement cascade and reduces inflammation.

Applications of Pozelimab Biosimilar

Pozelimab Biosimilar has shown promising results in preclinical studies for a range of autoimmune and inflammatory diseases, including:

• Rheumatoid arthritis
• Lupus
• Multiple sclerosis
• Inflammatory bowel disease
• Psoriasis

Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and damage to the joints. Pozelimab Biosimilar has shown efficacy in preclinical studies by reducing joint inflammation and preventing joint destruction. It has also been shown to improve symptoms and decrease disease activity in animal models of RA.

Lupus

Lupus is a complex autoimmune disease that can affect multiple organs, including the skin, joints, and kidneys. Pozelimab Biosimilar has shown potential as a treatment for lupus by reducing inflammation and preventing tissue damage. In preclinical studies, it has also been shown to improve kidney function and decrease autoantibody levels.

Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. Pozelimab Biosimilar has shown promise in preclinical studies by reducing inflammation and preventing demyelination, which is the hallmark of MS. It has also been shown to improve motor function and decrease disease severity in animal models of MS.

Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders of the digestive tract, including Crohn’s disease and ulcerative colitis. Pozelimab Biosimilar has shown efficacy in preclinical studies by reducing inflammation and improving disease activity in animal models of IBD. It has also been shown to improve intestinal barrier function and decrease tissue damage.

Psoriasis

Psoriasis is a chronic inflammatory skin disease characterized by red, scaly patches on the skin. Pozelimab Biosimilar has shown potential as a treatment for psoriasis by reducing inflammation and improving skin lesions in preclinical studies. It has also been shown to decrease the production of pro-inflammatory cytokines, which play a crucial role in the development of psoriasis.

Conclusion

In summary, Pozelimab Biosimilar is a promising research grade monoclonal antibody that targets the complement component 5 (C5) protein. It has shown efficacy in preclinical studies for a range of autoimmune and inflammatory diseases and has the potential to provide a new treatment option for patients. Further clinical trials are needed to fully evaluate the safety and efficacy of this novel therapeutic

SDS-PAGE for Pozelimab Biosimilar - Anti-C5 mAb

Pozelimab Biosimilar - Anti-C5 mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.