Golimumab is a human IgG1? monoclonal antibody, developped from genetically engineered mice immunized with human TNF?. Golimumab binds to and inhibits soluble and transmembrane human TNF?. Elevated TNF? is related to chronic inflammation. Therefore, golimumab can be used in adults,for the treatment of active rheumatoid arthritis (RA), active psoriatic arthritis ( PsA), active ankylosing spondylitis (AS), ulcerative colitis (UC). In the United States and Canada, golimumab is sold under the Simponi® brand. The FDA label includes a black box that warns of serious infections and malignant tumors.
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