Recombinant Human ELMO1, N-His

Description of Recombinant Human ELMO1, N-His

Introduction to Recombinant Human ELMO1

Recombinant Human ELMO1 is a protein that is commonly used in scientific research and has a wide range of applications in the field of immunology and cell biology. This protein is a recombinant form of the human ELMO1 gene, which encodes for a protein that plays a crucial role in cell signaling and immune response. In this article, we will discuss the structure, activity, and applications of Recombinant Human ELMO1.

Structure of Recombinant Human ELMO1

Recombinant Human ELMO1 is a 98 kDa protein that is composed of 890 amino acids. It belongs to the ELMO (Engulfment and Cell Motility) protein family and is highly conserved among different species. The protein has a modular structure, consisting of an N-terminal SH3 domain, a central PH (Pleckstrin Homology) domain, and a C-terminal ELMO domain. These domains are essential for the protein’s function and play a role in its interaction with other proteins.

The SH3 domain of Recombinant Human ELMO1 is responsible for protein-protein interactions and is involved in the activation of downstream signaling pathways. The PH domain, on the other hand, is responsible for binding to phospholipids and plays a role in the localization of the protein to the cell membrane. The ELMO domain is responsible for binding to other proteins, such as the DOCK (dedicator of cytokinesis) family of proteins, which are essential for ELMO1’s function in cell signaling and immune response.

Activity of Recombinant Human ELMO1

Recombinant Human ELMO1 is a key player in the process of phagocytosis, which is the engulfment and removal of foreign particles and dead cells by immune cells. It is involved in the activation of the Rho family of GTPases, which are essential for the formation of actin filaments and the rearrangement of the cytoskeleton during phagocytosis. ELMO1 also plays a role in the regulation of cell migration and adhesion, which are crucial processes in immune response and tissue repair.

The activity of Recombinant Human ELMO1 is regulated by its interaction with other proteins, such as the DOCK family of proteins, which act as guanine nucleotide exchange factors (GEFs) for the Rho GTPases. These interactions lead to the activation of downstream signaling pathways, such as the Rac1 and Cdc42 pathways, which are essential for the proper functioning of ELMO1 in cell signaling and immune response.

Applications of Recombinant Human ELMO1

Recombinant Human ELMO1 has a wide range of applications in scientific research, particularly in the fields of immunology and cell biology. It is commonly used as an antigen in experiments to study the role of ELMO1 in phagocytosis, cell migration, and adhesion. The protein can also be used to study the interactions between ELMO1 and other proteins, such as the DOCK family of proteins, which are essential for its function.

Furthermore, Recombinant Human ELMO1 can also be used in drug discovery and development. Since ELMO1 plays a crucial role in cell signaling and immune response, it is a potential target for the development of therapeutic drugs for various diseases, such as autoimmune disorders and cancer. By studying the structure and activity of Recombinant Human ELMO1, researchers can gain a better understanding of its role in disease and develop targeted therapies to modulate its function.

Conclusion

In summary, Recombinant Human ELMO1 is a protein that plays a crucial role in cell signaling and immune response. Its modular structure and interactions with other proteins make it an essential component in the process of phagocytosis, cell migration, and adhesion. This protein has