Best Prices:
from
2.12$ /AA
High-quality peptides at competitive prices are just one click away! Starting at 2.12$ per amino acid, you can generate synthetic peptides up to 150 residues with an unlimited range of modifications and pay only if you’re satisfied with your order. In just a few clicks, fill out the form to receive an instant quote and order directly from our shop using the secure online payment system. Start your custom peptide synthesis now!
– Our success rate is higher than most other custom service suppliers.
– We have a strong experience in synthesizing difficult peptides: 100 to 150AA long peptides, hydrophobic peptides or repeated sequences…
– We provide the best prices together with guaranteed high quality standards.
– Our professional and pleasant sales team is devoted to serve our custom peptide synthesis clients carefully.
– We keep improving our fast delivery service.
– We offer a large range of possible conjugations and modifications.
– Purchasing peptide synthesis is very easy and fast at ProteoGenix!
– We provide high quality peptide synthesis for research.
Brief shortlist of all available peptide related services offered by ProteoGenix:
– fmoc solid phase Peptide synthesis
– Large range of Peptide modifications
– Peptide library synthesis and design
– Small to large scale peptide synthesis from mgs to kgs
– Simple, complex and circular peptide synthesis, with large repeats
– Very long sequences of more than 150 mer
– HPLC purities ranging from crude to above 99%
– Multiple Antigenic Peptides (MAPs)
– Use of special or unnatural amino acids like Homo-tyrosine, DL-m-tyrosine, Nal, Pal, 4-Cl-Phe-OH, D-amino acids, phosphotyrosine, beta amino acids…
– Arrays and libraries for screening or epitope mapping purposes
– Peptide content analysis (N%)
Peptide #1
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Custom peptide synthesis
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Sequence, purity and quantity guaranteed Lyophilized peptides COA MS and HPLC profiles (except for crude/desalted peptides)
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The most competitive price for peptide synthesis on the market.
We guarantee to provide you with the most competitive price.
Save time and buy your peptides thanks to our online form. Delivery in 10 business days.
ProteoGenix can synthesize peptides up to 150 AA.
ProteoGenix offers an unlimited range of peptide modifications.
Your project is our priority so we will start from the beginning until we get the right peptide or you won’t pay a thing.
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At ProteoGenix, we offer recombinant expression and semisynthesis
(ligation of synthetic and recombinant fragments) in addition to the
standard Fmoc solid-phase synthesis. If you are working with complex
structures, reach out to our team to learn how we can help.
If you are looking for an expert’s advice to help you maximize the stability and yield of your synthetic peptide while keeping production costs low, reach out to our team for more information.
The most commonly used method to test solubility is based on charge determination. For small peptides with up to 5 amino-acids, distilled water remains the first option. For other cases, you can refer to this guide:
Synthetic antigenic peptides represent powerful tools for polyclonal or monoclonal antibody generation and as components of peptide vaccines. For these applications, peptides need to be designed with two properties in mind: antigenicity and immunogenicity.The first term is used to describe the ability of an antigen to interact with an antibody’s functional binding site, while the second term describes a peptide’s ability to elicit a humoral an/or cellular immune response. For effective vaccine and antibody production, peptides must have both properties.
Enhancing peptide antigenicity can be achieved by:
Peptide immunogenicity can be maximized by coupling synthetic peptides with carriers keeping the following recommendations in mind:
Many peptide drugs are generated by chemical modification of natural molecules. These drugs remain invaluable for the treatment of multiple metabolic diseases.
Vaccines are considered one of the most successful strategies of modern medicine. Conventional vaccines have relied heavily in inactive pathogens to elicit an immune response, making them hard to produce. In contrast, peptide vaccines are increasingly considered as a cost-effective, safer, and highly specific alternative.
The discovery of cell adhesion and self-assembling peptides has opened up a new window of opportunity in tissue engineering applications. These peptides are increasingly used as bioactive molecules to support cellular growth and tissue regeneration.
Cell-penetrating peptides and self-assembling peptides are two increasingly important bioactive components of advanced gene and drug delivery applications . In comparison to conventional methods that make use of viral vectors, peptides are much easier to synthesize, thus, helping make the technology more accessible and widespread.
Many personal care products harness the beneficial properties of cosmetic peptides . Small peptides able to cross the skin barrier are often incorporated in cosmetics due to their easy diffusion allied to their protective and regenerative properties. Peptides with antimicrobial properties are also often incorporated in creams to prevent and treat several well-known skin conditions.
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Solid-phase peptide synthesis has dominated the market for custom production in the last couple of decades. The method, initially developed in the 1950s, has matured into a technology that remains unparalleled in terms of automation, cost-effectiveness, scalability, lead times, and yields.
This method is traditionally carried out on a solid support in a stepwise manner from the C to the N terminus. Nα-protected amino acids are used to control the direction of the synthesis process and thus minimize side reactions. Today, solid-phase synthesis makes use of two major N-terminus protective groups: Boc (t-butyloxycarbonyl) and Fmoc (9-fluorenylmethoxycarbonyl).
In addition to these protective groups, permanent protection groups are often attached to side chains. These groups prevent unwanted branching and can withstand several cycles of chemical treatment during the synthesis process. They are only removed in the final stage of the process using strong acids. Benzyl (Bzl) and tert-butyl (tBu) are two of the most widely used side chain protection groups.
The stepwise synthesis of peptides is carried out as follows:
The use of strong chemicals to produce synthetic peptides may offer a challenge when it comes to purification. To overcome this limitation, liquid-phase synthesis is often employed to achieve GMP-grade peptide production. Despite being significantly more time-consuming and leading to lower yields than solid-phase synthesis, liquid-phase methods are still sparingly used to produce highly pure short peptides (<10 AA) for some applications.
Both solid-phase and liquid-phase synthesis are chemical methods for linear peptide production. When large peptides with complex secondary or tertiary structures are required, recombinant expression is a much better alternative. However, despite being able a good method to produce long peptides, recombinant expression suffers from an important disadvantage – it is restricted to natural amino acids produced and processed by the host organism.
For this reason, when peptides with complex structures and unnatural amino acids need to be produced, a semisynthetic approach may be ideal.
Despite the high efficiency of most peptide synthesis methods, many of these processes may still generate undesired impurities due to incomplete deprotection, unwanted reactions between free protecting groups, truncation and/or deletion of amino acids, isomers, and other side products.
Removal of these impurities is recurrently achieved by using one or several purification techniques:
Among these, RP-HPLC is the most widely used process of purification. Unlike conventional HPLC that separates products according to the concentration of polar solvents on the mobile phase, RP-HPLC captures hydrophobic molecules from aqueous solutions and releases them in function of their hydrophobicity. This makes it easier to separate correctly synthesized peptides from undesired impurities.
