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Choose between several hosts
Choose between P. pastoris and S. cerevisiae for your protein expression.
Access a complete yeast expression toolbox
We propose different strains of P. pastoris orS. cerevisiaeto optimize your protein production.
Unrivalled protein production expertise
With 1500+ protein expression, you can trust our expertise.
Integrated solution from gene to protein
From optimized gene to protein, we are your protein expression partner!
PhD account managers
At ProteoGenix, a PhD account manager assists you!
Cost effective expression system
Yeasts are known for their fast growth rate and high yield protein expression.
Expression vector construction(optional)
Small scale protein expression
Protein expression scale up and purification
The choice of the host organism is of primary importance once the decision to perform yeast protein expression is taken. A lot of host cells are described in the literature. However, S. cerevisiae and P. pastoris are the most widely used.
This latest offers several advantages when it comes to protein expression such as:
To conclude, Pichia pastoris protein expression is the first choice for the production of secreted proteins. Pichia pastoris remains also a relevant option when it comes to therapeutic protein production. This organism was used as yeast host for the expression of several therapeutic proteins reaching the market such as:
As a unicellular organism, S. cerevisiae and other yeasts include the same advantages as prokaryotic systems such as E. coli. Thus, S. cerevisiae is characterized by short generation times, high biomass yields and well-characterized tools for DNA manipulation.
Among all these advantages, protein expression offers also additional benefits compared to E. coli expression. This includes:
Overall, S.cerevisiae has been extensively studied and benefits from a wide range of tools (strains, expression vectors…). Taking these aspects into consideration, S. cerevisiae is the perfect host for projects requiring testing of several conditions. As Pichia pastoris, S. cerevisiae has been widely used for therapeutic protein expression. However, if more “human”-like glycosylation would be necessary, baculovirus or mammalian cell protein expression will be preferred.
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