XtenCHO ™ Cell Bank Pack

Reference: PX-XTE-005
Expression systemEukaryotic expression
Delivery conditionDry Ice
Delivery lead time in business daysEurope: 5-7 business days
USA & Canada: 7-10 business days
Rest of the world: 5-12 business days
Storage conditionLiquid Nitrogen
Host speciesMammalian cells
ReferencePX-XTE-005
NoteFor research use only
Kit Content6 x 1 ml of frozen XtenCHO™ Cells
Limited Use Label LicensesLimited Use Label License for internal Research and Development Use of Mammalian Cell Lines Notice to Purchaser: The purchase of this product conveys to the purchaser the limited, non-transferable right to use the purchased amount of the product and progeny, to perform internal research and development for the sole benefit of the purchaser. The purchase of this product does not grant the purchaser any additional rights, including, without limitation: (a) the right to use the product or its components in commercial applications of any kind, including bioproduction (e.g. use of the product to manufacture therapeutic agents or diagnostic test components, such as proteins, antibodies, viral particles or virus-like particles), quality control and commercial services such as reporting the results of purchaser’s activities for a fee or other form of consideration; (b) the right to use the product or its components as a therapeutic agent or diagnostic test component; (c) the right to use the product or its components to produce material for use in human clinical trials; or (d) the right to transfer or resell the product or its components in any form, progeny or derivative. For information on obtaining additional rights, please contact us at contact@proteogenix.fr, Licensing and Commercial Supply, ProteoGenix, 19 rue de La Haye 67300 Schiltigheim, France. TRADEMARKS: All trademarks are the property of ProteoGenix and its subsidiaries unless otherwise specified.

The XtenCHO™ Cell line has been an internal tool for years at ProteoGenix! These extremely powerful cells are now available for you!
In the last years, biotherapeutics represent more than half of the total approved drugs. Most of them include monoclonal antibodies. Biotherapeutics bear post-translational modifications, are often large and complex. A stable cell line like XtenCHO™ which is able to produce these proteins is a valuable tool for therapeutic development.
ProteoGenix uses this cell line routinely to produce its recombinant protein for its customers. Given the willingness of our customers to use it we now offer it in our catalog.

XtenCHO™ Cells characteristics

The XtenCHO™ Cells are derived from Chinese Hamster Ovarian CHO-K1 cell line. They have been optimized to sustain extended transient gene expression. The genetic modifications enhance plasmid-driven expression and increase plasmid maintenance. Indeed, the XtenCHO™ Cells can maintain the transfected plasmid for 14 days without feeding making them produce on a longer period. The XtenCHO™ Cells are well adapted to high-density suspension culture. The XtenCHO™ Expression Medium has been specifically developed to be supplied to these cells for high viability and high growth cultures. The XtenCHO™ Cells have a doubling time of approximately 23 hours. These cells are also very robust and easy to cultivate, their recovery time after thawing is about 2 days.
The XtenCHO™ Cells provide the highest protein expression level on the market! In combination with the XtenCHO™ Transfection Kit, the record yield of 904 mg/mL has been achieved with a recombinant antibody. Moreover, these cells can produce a wide range of proteins and antibodies including pentameric IgMs. Being derived from CHO cells they perform human-like glycosylations and are resistant to viral infections.
The XtenCHO™ Cells are key components of the XtenCHO™ Starter Kit. Cells are also provided in 6 vials of 1mL format in the XtenCHO™ Cell Bank.
The XtenCHO™ Cell line has been an internal tool for years at ProteoGenix! These extremely powerful cells are now available for you!
In the last years, biotherapeutics represent more than half of the total approved drugs. Most of them include monoclonal antibodies. Biotherapeutics bear post-translational modifications, are often large and complex. A stable cell line like XtenCHO™ which is able to produce these proteins is a valuable tool for therapeutic development.
ProteoGenix uses this cell line routinely to produce its recombinant protein for its customers. Given the willingness of our customers to use it we now offer it in our catalog.

XtenCHO™ Cells characteristics

The XtenCHO™ Cells are derived from Chinese Hamster Ovarian CHO-K1 cell line. They have been optimized to sustain extended transient gene expression. The genetic modifications enhance plasmid-driven expression and increase plasmid maintenance. Indeed, the XtenCHO™ Cells can maintain the transfected plasmid for 14 days without feeding making them produce on a longer period. The XtenCHO™ Cells are well adapted to high-density suspension culture. The XtenCHO™ Expression Medium has been specifically developed to be supplied to these cells for high viability and high growth cultures. The XtenCHO™ Cells have a doubling time of approximately 23 hours. These cells are also very robust and easy to cultivate, their recovery time after thawing is about 2 days.
The XtenCHO™ Cells provide the highest protein expression level on the market! In combination with the XtenCHO™ Transfection Kit, the record yield of 904 mg/mL has been achieved with a recombinant antibody. Moreover, these cells can produce a wide range of proteins and antibodies including pentameric IgMs. Being derived from CHO cells they perform human-like glycosylations and are resistant to viral infections.
The XtenCHO™ Cells are key components of the XtenCHO™ Starter Kit. Cells are also provided in 6 vials of 1mL format in the XtenCHO™ Cell Bank.
1 box : XtenCHO™ Cell Bank Pack : 6 vials

Up to 10x higher yields without supplemental feeds

Therapeutic antibodies from several IgG subclasses and isotypes (IgG1-kappa and lambda, IgG2-lambda, IgG4-kappa) were produced with XtenCHO ™ cells and in parallel with CHO-S ™ and ExpiCHO ™ expression systems. XtenCHO ™ cells were transfected with ProteoGenix' proprietary TGE system (transfection protocol, transfection reagent and culture medium). CHO-S ™and ExpiCHO ™ cells were transfected according to manufacturer's instructions for each expression system (protocol, reagents and culture medium). Determination of production yields was done with an Octet Red96 system (Protein G biosensor).

Publication

  • Luo K, Chen Y, Wang F. Shrimp Plasma MANF Works as an Invertebrate Anti-Inflammatory Factor via a Conserved Receptor Tyrosine Phosphatase. J Immunol. 2022 Mar 1;208(5):1214-1223. doi: 10.4049/jimmunol.2100595. Epub 2022 Feb 11. PMID: 35149533.
  • Bonduelle O, Chaudesaigues C, Tolazzi M, Suleiman E, de Bernard S, Alves K, Nourikyan J, Bohec M, Baudrin LG, Katinger D, Debré P, Scarlatti G, Vieillard V, Combadière B. Dichotomy in Neutralizing Antibody Induction to Peptide-Conjugated Vaccine in Squalene Emulsion Contrast With Aluminum Hydroxide Formulation. Front Immunol. 2022 Apr 7;13:848571. doi: 10.3389/fimmu.2022.848571. PMID: 35464449; PMCID: PMC9021396.
  • Sandberg, A., Berenjeno-Correa, E., Rodriguez, R.C. et al. Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts. Alz Res Therapy 14, 196 (2022). https://doi.org/10.1186/s13195-022-01141-1
  • Villatoro, A., Cuminetti, V., Bernal, A. et al. Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation. Nat Commun 14, 12 (2023). https://doi.org/10.1038/s41467-022-35700-9

Reviews

There are no reviews yet.

REVIEW YOUR PRODUCT

Be the first to review “XtenCHO ™ Cell Bank Pack”

Your email address will not be published. Required fields are marked *

Related products

XtenCHO ™ Starter kit
XtenCHO

XtenCHO ™ Starter kit

PX-XTE-001 1880$
XtenCHO ™ Expression medium
XtenCHO

XtenCHO ™ Expression medium

PX-XTE-002 310$
XtenCHO ™ Transfection kit
XtenCHO

XtenCHO ™ Transfection kit

PX-XTE-003 730$
XtenCHO ™ Cell Bank Pack
XtenCHO

XtenCHO ™ Cell Bank Pack

PX-XTE-005 2615$

Contact us

Send us a message from the form below







    Cart (0 Items)

    Your cart is currently empty.

    View Products