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Mass spectrometry (MS)

Mass spectrometry (MS) is an analytical tool that determines the precise mass of molecules. The measured value is the ratio of mass over charge of synthetic ions. These ions are… Read more
18 Products
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Anti-H3K4me3 Antibody (304M3-B)

Reference

ARO-A15090

size

100ug

Isotype

IgG1, kappa

Applications

Elisa, IP, MS, WB

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti- Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human ATAD2B IP Antibody (SAA0243)

Reference

ARO-A15174

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human BAZ2B IP Antibody (SAA0244)

Reference

ARO-A15178

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human BRD2 IP Antibody (SAA0190)

Reference

ARO-A15189

size

100ug

Isotype

IgG

Applications

Elisa, IF, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human BRD4 IP Antibody (SAA0192)

Reference

ARO-A15195

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human CBX1 IP Antibody (SAA0195)

Reference

ARO-A15204

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human DOT1L IP Monoclonal Antibody, SAA0200

Reference

PTX19159-100

size

100ug

Isotype

IgG

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

ProteoGenix

$452.00

Anti-Human EED IP Antibody (SAA0245)

Reference

ARO-A15182

size

100ug

Isotype

IgG

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human EP300 IP Antibody (SAA0246)

Reference

ARO-A15135

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human L3MBTL3 IP Antibody (SAA0209)

Reference

ARO-A15133

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human MBTD1 IP Antibody (SAA0210)

Reference

ARO-A15137

size

100ug

Isotype

IgG

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human PBK IP Monoclonal Antibody, SAA0214

Reference

PTX19162-100

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

ProteoGenix

$452.00

Anti-Human PRDM11 IP Antibody (SAA0217)

Reference

ARO-A15152

size

100ug

Isotype

IgG

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human SCML2 IP Antibody (SAA0220)

Reference

ARO-A15161

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human SETD2 IP Antibody (SAA0221)

Reference

ARO-A15164

size

100ug

Isotype

IgG

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

Anti-Human TDRKH IP Antibody (SAA0235)

Reference

ARO-A15156

size

100ug

Isotype

IgG1

Applications

Elisa, IF, IP, MS

Host Species

Mouse

Clonality

Monoclonal Antibody

Target species

Anti-Human Monoclonal Antibody

Brand

Arovia

$462.00

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    Mass Spectrometry

    Mass spectrometry (MS) is an analytical tool that determines the precise mass of molecules. The measured value is the ratio of mass over charge of synthetic ions. These ions are generated inside the mass spectrometer from the sample. This may be used to identify a molecule after a separation process as liquid chromatography (LC) for example. Moreover, information about configuration may be found thanks to macromolecules fragmentation. In protein studies, the peptidic chain is cut into smaller ions whose nature depends on the bond that was cleaved and the atom receiving the charge coming from the cleavage. Tandem mass spectrometry (MS/MS) fragments further the former ions to give son ions whose masses can be accurately measured. This technique has been applied in proteomics to sequence proteins. It also provides information on modifiers or other conjugated molecules that the protein may carry.

    Mass Spectrometry on Antibodies

    Mass spectrometry may thus be applied to antibodies. In addition to sequencing, it allows to know the post translational modifications such as glycosylations which are critical quality attributes for the antibodies’ characterization. The oxidation level and subunit characterization can be analyzed as well. It may also be used in antibody drug conjugates (ADC) development to control the conjugation of the additional molecules. These data may be important as they impact the affinity, stability, or aggregation of antibodies. They are critical parameters in the development of therapeutic or diagnostic antibodies for example. To achieve these analysis different pathways may be chosen depending on the needed accuracy and time availability. Top-down strategy is the study of the intact mass whereas bottom-up is the fragmentation at the peptide level. A middle technique can be used also to separate the subunits and the glycans. ProteoGenix offers a range of stable isotope labeled antibodies. These tools will prove useful as internal standards for MS identification and quantification.

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