Cobolimab Biosimilar – Anti-HAVCR2, TIM3, CD366 mAb – Research Grade

Description of Cobolimab Biosimilar - Anti-HAVCR2, TIM3, CD366 mAb - Research Grade

Introduction:

Cobolimab Biosimilar is a research grade antibody that targets the immune checkpoint proteins HAVCR2, TIM3, and CD366. This novel therapy has shown promising results in preclinical studies and has the potential to be a valuable addition to the treatment options for various diseases.

Structure of Cobolimab Biosimilar:

Cobolimab Biosimilar is a monoclonal antibody (mAb) that is produced through recombinant DNA technology. It is a fully humanized antibody, meaning that it is derived from human genetic material and has a high affinity for its target proteins. The antibody has a molecular weight of approximately 150 kDa and consists of two heavy chains and two light chains that are linked together by disulfide bonds. The structure of Cobolimab Biosimilar is designed to specifically bind to the target proteins and modulate their activity.

Activity of Cobolimab Biosimilar:

Cobolimab Biosimilar is a potent inhibitor of three immune checkpoint proteins – HAVCR2, TIM3, and CD366. These proteins play a crucial role in regulating the immune response and preventing excessive inflammation. However, in certain diseases, these proteins can be overexpressed and contribute to disease progression. Cobolimab Biosimilar binds to these proteins and blocks their activity, thereby restoring the balance of the immune system.

Application of Cobolimab Biosimilar:

1. Treatment of autoimmune diseases:

Autoimmune diseases are characterized by an overactive immune response, leading to damage to healthy tissues. Cobolimab Biosimilar has shown promising results in preclinical studies for the treatment of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and lupus. By targeting the immune checkpoint proteins, Cobolimab Biosimilar can help regulate the immune response and reduce the symptoms of these diseases.

2. Cancer therapy:

Immune checkpoint proteins play a crucial role in cancer progression by suppressing the immune response against cancer cells. Cobolimab Biosimilar has the potential to enhance the anti-tumor immune response by blocking the activity of these proteins. Preclinical studies have shown that Cobolimab Biosimilar can inhibit tumor growth and improve the efficacy of other cancer therapies.

3. Infectious diseases:

Infectious diseases such as hepatitis, HIV, and tuberculosis can also benefit from Cobolimab Biosimilar therapy. By targeting HAVCR2, TIM3, and CD366, Cobolimab Biosimilar can enhance the immune response against these pathogens and improve the efficacy of existing treatments.

4. Transplant rejection:

Organ transplant recipients often require lifelong immunosuppressive therapy to prevent rejection of the transplanted organ. Cobolimab Biosimilar has the potential to reduce the need for immunosuppressive drugs by regulating the immune response and preventing rejection.

5. Inflammatory disorders:

Inflammatory disorders such as asthma, psoriasis, and inflammatory bowel disease are characterized by chronic inflammation. Cobolimab Biosimilar can modulate the immune response and reduce inflammation, making it a potential therapy for these conditions.

Conclusion:

Cobolimab Biosimilar is a promising research grade antibody that targets the immune checkpoint proteins HAVCR2, TIM3, and CD366. Its unique structure and mechanism of action make it a potential therapy for a wide range of diseases, including autoimmune diseases, cancer, infectious diseases, transplant rejection, and inflammatory disorders. Further clinical studies are needed to fully explore the therapeutic potential of Cobolimab Biosimilar and bring this novel therapy to patients in need.

SDS-PAGE for Cobolimab Biosimilar - Anti-HAVCR2, TIM3, CD366 mAb

Cobolimab Biosimilar - Anti-HAVCR2, TIM3, CD366 mAb, on SDS-PAGE under reducing and non-reducing conditions. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.

Immobilized CD366 / HAVCR2 / TIM-3, C-His, recombinant protein (cat. No.PX-P5623) at 0.5µg/mL (100µL/well) can bind to Cobolimab Biosimilar - Anti-HAVCR2, TIM3, CD366 mAb (cat. No.PX-TA1544) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450