Recombinant Human GNAO1 Protein, N-His

Description of Recombinant Human GNAO1 Protein, N-His

Introduction

Recombinant Human GNAO1 Protein, also known as Guanine Nucleotide Binding Protein Alpha O Subunit, is a protein that plays a crucial role in various cellular processes. This protein is produced through the process of genetic recombination, making it a highly purified and biologically active form of the protein. In this article, we will explore the structure, activity, and applications of Recombinant Human GNAO1 Protein.

Structure of Recombinant Human GNAO1 Protein

The GNAO1 protein is a member of the G protein family, which are signaling molecules involved in transmitting signals from outside the cell to the inside. The recombinant form of this protein is produced in a laboratory setting using recombinant DNA technology. This involves inserting the gene for GNAO1 into a suitable host organism, such as bacteria, and allowing it to produce the protein. The resulting protein is then purified to remove any impurities, resulting in a highly concentrated and biologically active form of GNAO1.

The structure of Recombinant Human GNAO1 Protein consists of three subunits, namely alpha, beta, and gamma. The alpha subunit is responsible for binding to guanine nucleotides, while the beta and gamma subunits are involved in interacting with other proteins. The alpha subunit also contains a lipid anchor, which allows it to attach to the cell membrane and initiate signaling pathways.

Activity of Recombinant Human GNAO1 Protein

The primary function of GNAO1 protein is to act as a molecular switch, turning on or off various signaling pathways within the cell. This is achieved by binding to guanine nucleotides, which results in a conformational change in the protein. This change allows the protein to interact with other proteins, leading to the activation of downstream signaling pathways.

One of the key activities of GNAO1 protein is its involvement in the regulation of neurotransmitter release in the brain. It is found in high levels in the brain and is essential for proper communication between nerve cells. Mutations in the GNAO1 gene have been linked to neurological disorders such as epilepsy and movement disorders.

Additionally, GNAO1 protein is also involved in regulating cell growth and differentiation, as well as hormone secretion. It plays a crucial role in various physiological processes, making it a vital protein for maintaining the proper functioning of the body.

Applications of Recombinant Human GNAO1 Protein

The highly purified and biologically active form of Recombinant Human GNAO1 Protein has various applications in the field of research and medicine. It is commonly used as an antigen in studies investigating the role of GNAO1 in neurological disorders. The recombinant protein is also used in drug discovery and development, as it can be used to screen for potential drugs that target GNAO1 signaling pathways.

Furthermore, Recombinant Human GNAO1 Protein has potential therapeutic applications. It has been shown to have neuroprotective properties and may have a role in treating neurological disorders such as Parkinson’s disease and schizophrenia. Research is ongoing to explore the potential of this protein as a therapeutic target.

Conclusion

In summary, Recombinant Human GNAO1 Protein is a vital protein involved in various cellular processes. Its structure and activity make it a crucial molecule for maintaining proper cell signaling and function. The recombinant form of this protein has numerous applications in research and medicine, and its potential as a therapeutic target is currently being explored. Further studies on this protein may lead to a better understanding of its role in health and disease, ultimately leading to the development of new treatments for various disorders.