Recombinant Human PIEZO1 Protein, N-His

Description of Recombinant Human PIEZO1 Protein, N-His

Introduction to Recombinant Human PIEZO1 Protein

Recombinant Human PIEZO1 Protein, also known as Piezo-type mechanosensitive ion channel component 1, is a transmembrane protein that plays a crucial role in sensing mechanical stimuli in cells. It is encoded by the PIEZO1 gene and is highly expressed in a variety of tissues, including the lungs, heart, and skeletal muscles. This protein has gained significant attention in the scientific community due to its unique structure and function, making it a promising target for therapeutic interventions.

Structure of Recombinant Human PIEZO1 Protein

Recombinant Human PIEZO1 Protein is a large protein consisting of 2,880 amino acids. It is composed of three main domains – an N-terminal extracellular domain, a transmembrane domain, and a C-terminal cytoplasmic domain. The N-terminal domain contains multiple leucine-rich repeats, which are involved in protein-protein interactions. The transmembrane domain consists of 36 transmembrane helices, forming a funnel-like structure that spans the cell membrane. The C-terminal domain contains a highly conserved C-terminal sequence, which is essential for the channel’s activity.

Activity of Recombinant Human PIEZO1 Protein

Recombinant Human PIEZO1 Protein is a mechanosensitive ion channel, which means it can open and close in response to mechanical forces. It is activated by various mechanical stimuli, such as stretch, pressure, and shear stress. Upon activation, the channel opens and allows the influx of calcium ions into the cell, leading to various downstream signaling events. This influx of calcium ions is crucial for cellular processes such as cell migration, proliferation, and differentiation. Additionally, Recombinant Human PIEZO1 Protein has been shown to play a role in regulating blood pressure and red blood cell volume.

Application of Recombinant Human PIEZO1 Protein

Recombinant Human PIEZO1 Protein has been extensively studied for its potential therapeutic applications. One of the most promising applications is in the treatment of various cardiovascular diseases. As Recombinant Human PIEZO1 Protein is involved in regulating blood pressure, targeting this protein could potentially help in managing hypertension. Additionally, studies have shown that mutations in the PIEZO1 gene are associated with hereditary xerocytosis, a rare blood disorder characterized by abnormal red blood cell shape and decreased cell volume. Therefore, Recombinant Human PIEZO1 Protein could be a potential target for treating this disorder.

Furthermore, Recombinant Human PIEZO1 Protein has also been studied for its role in cancer. It has been found that this protein is overexpressed in various cancer types, and its activation promotes cancer cell migration and invasion. Therefore, targeting Recombinant Human PIEZO1 Protein could potentially inhibit cancer metastasis and improve patient outcomes.

In addition to its therapeutic applications, Recombinant Human PIEZO1 Protein has also been used in research studies to understand its role in various cellular processes. For instance, it has been shown to play a crucial role in the development of the nervous system and in regulating neuronal activity. Furthermore, Recombinant Human PIEZO1 Protein has been studied in the context of mechanotransduction, the process by which cells convert mechanical stimuli into biochemical signals.

In conclusion, Recombinant Human PIEZO1 Protein is a fascinating protein with a unique structure and function. Its role in sensing mechanical stimuli and its potential therapeutic applications make it an exciting target for further research. As our understanding of this protein continues to grow, it could open up new avenues for the development of novel treatments for various diseases.