Recombinant Human ROR1/NTRKR1 Protein, N-His

Description of Recombinant Human ROR1/NTRKR1 Protein, N-His

Introduction

The Recombinant Human ROR1/NTRKR1 Protein is a synthetic protein that is produced through genetic engineering techniques. It is a fusion protein consisting of the extracellular domain of the human receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the Fc region of human immunoglobulin G1 (IgG1). This recombinant protein has been extensively studied and has shown promising results in various research areas. In this article, we will discuss the structure, activity, and applications of Recombinant Human ROR1/NTRKR1 Protein.

Structure of Recombinant Human ROR1/NTRKR1 Protein

The Recombinant Human ROR1/NTRKR1 Protein has a complex structure, consisting of two main components: the extracellular domain of ROR1 and the Fc region of IgG1. The extracellular domain of ROR1 is responsible for binding to its ligand, Wnt5a, and activating downstream signaling pathways. It is composed of three distinct domains: an immunoglobulin-like domain, a cysteine-rich domain, and a kringle domain. The Fc region of IgG1 provides stability to the protein and allows for easy purification and detection.

Activity of Recombinant Human ROR1/NTRKR1 Protein

The main activity of Recombinant Human ROR1/NTRKR1 Protein is its ability to bind to its ligand, Wnt5a. This binding triggers a cascade of signaling events that ultimately regulate cell growth, differentiation, and migration. The ROR1/Wnt5a signaling pathway has been implicated in various physiological processes, including embryonic development, tissue homeostasis, and immune response. Additionally, aberrant activation of this pathway has been linked to several diseases, such as cancer, autoimmune disorders, and neurodegenerative diseases.

Applications of Recombinant Human ROR1/NTRKR1 Protein

The unique structure and activity of Recombinant Human ROR1/NTRKR1 Protein make it a valuable tool in various research areas. Here are some of its applications:

Cancer Research

The ROR1/Wnt5a signaling pathway has been extensively studied in cancer biology, and Recombinant Human ROR1/NTRKR1 Protein has been used to investigate its role in tumor growth and progression. Studies have shown that ROR1 is overexpressed in various types of cancer, including breast, lung, and pancreatic cancer. Recombinant Human ROR1/NTRKR1 Protein has been used to inhibit ROR1 activity and block tumor growth in preclinical models, making it a potential target for cancer therapy.

Immunology

The ROR1/Wnt5a signaling pathway has also been implicated in immune response regulation. Recombinant Human ROR1/NTRKR1 Protein has been used to study the role of ROR1 in immune cell development and function. It has also been used to investigate the potential of targeting ROR1 as a treatment for autoimmune disorders.

Neuroscience

Recent studies have identified a link between the ROR1/Wnt5a signaling pathway and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. Recombinant Human ROR1/NTRKR1 Protein has been used to study the role of ROR1 in neuronal development and function. It has also shown potential as a therapeutic target for these diseases.

Drug Development

The ROR1/Wnt5a signaling pathway has been identified as a potential target for drug development in various diseases. Recombinant Human ROR1/NTRKR1 Protein has been used to screen for small molecule inhibitors of ROR1 activity. It has also been used in drug conjugation studies to improve the specificity and efficacy of targeted therapies.

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