Recombinant Human SLC30A3, N-His

Description of Recombinant Human SLC30A3, N-His

Introduction to Recombinant Human SLC30A3

Recombinant Human SLC30A3, also known as Solute Carrier Family 30 Member 3, is a protein that belongs to the SLC30 family of zinc transporters. This protein is encoded by the SLC30A3 gene and is primarily found in the cytoplasm of cells. It plays a crucial role in maintaining the proper levels of zinc within the cell, which is essential for various cellular processes.

Structure of Recombinant Human SLC30A3

The recombinant form of SLC30A3 is a 374 amino acid protein with a predicted molecular weight of approximately 41 kDa. It contains six transmembrane domains and a large cytoplasmic loop that is responsible for the transport of zinc ions. The protein also has a conserved histidine-rich region that acts as a zinc-binding site.

Activity of Recombinant Human SLC30A3

Recombinant Human SLC30A3 is a zinc transporter that facilitates the transport of zinc ions across the cell membrane. This protein is primarily expressed in cells that require high levels of zinc, such as pancreatic beta cells, intestinal epithelial cells, and immune cells. It plays a crucial role in maintaining the intracellular zinc homeostasis, which is essential for various cellular processes such as gene expression, cell signaling, and enzymatic activity.

The transport activity of SLC30A3 is regulated by various factors, including zinc availability, pH, and redox state. Under normal conditions, the protein transports zinc ions out of the cell, preventing zinc toxicity. However, in zinc-deficient conditions, SLC30A3 can transport zinc ions into the cell to maintain the proper levels of this essential micronutrient.

Application of Recombinant Human SLC30A3

Recombinant Human SLC30A3 has various applications in both research and clinical settings. Its role in regulating zinc homeostasis makes it a valuable tool for studying the effect of zinc on cellular processes. It is also used in studies involving zinc deficiency and toxicity, as well as in understanding the role of zinc in various diseases.

In clinical settings, SLC30A3 has been linked to several diseases, including type 2 diabetes, Alzheimer’s disease, and certain types of cancer. Its role in regulating zinc levels in the pancreas makes it a potential target for the treatment of diabetes. In addition, SLC30A3 has been shown to play a role in the development of Alzheimer’s disease, making it a potential therapeutic target for this neurodegenerative disorder.

Furthermore, the expression of SLC30A3 has been found to be altered in certain types of cancer, including breast cancer and prostate cancer. This suggests that SLC30A3 may play a role in the development and progression of these cancers, making it a potential target for cancer treatment.

Conclusion

In conclusion, Recombinant Human SLC30A3 is a zinc transporter that plays a crucial role in maintaining the proper levels of zinc within the cell. Its structure, activity, and application make it a valuable tool for studying the role of zinc in various cellular processes and diseases. Further research on this protein may lead to the development of new treatments for diseases such as diabetes, Alzheimer’s disease, and cancer.