No services found
No Products found
100ug
AntibodySystem
Recombinant Proteins
Recombinant Human TAC1 Protein, also known as Substance P or Neurokinin 1, is a neuropeptide that plays a crucial role in various physiological processes such as pain perception, inflammation, and stress response. This protein is encoded by the TAC1 gene and is produced by the nervous system, immune cells, and other tissues in the body. In recent years, the production of recombinant TAC1 protein has gained significant attention in the field of biotechnology due to its potential therapeutic applications.
The structure of Recombinant Human TAC1 Protein consists of 11 amino acids, with the sequence Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met. This peptide is highly conserved among different species and is characterized by a C-terminal amidation, which is essential for its biological activity. The three-dimensional structure of TAC1 protein is composed of two alpha-helices connected by a loop region, which forms a hairpin-like structure. This structure is crucial for the binding of TAC1 protein to its receptor and activation of downstream signaling pathways.
Recombinant Human TAC1 Protein is a potent agonist of the neurokinin 1 receptor (NK1R), a G-protein coupled receptor that is widely expressed in the central and peripheral nervous system. Upon binding to NK1R, TAC1 protein triggers a cascade of signaling events, including the activation of phospholipase C, release of intracellular calcium, and activation of protein kinase C. These signaling pathways ultimately lead to the release of pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor, and the sensitization of nociceptive neurons, resulting in pain perception.
In addition to its role in pain perception, TAC1 protein has been shown to play a crucial role in other physiological processes, such as inflammation, stress response, and immune function. TAC1 protein has been found to be upregulated in response to various inflammatory stimuli, and its release can contribute to the recruitment of immune cells to the site of inflammation. Moreover, TAC1 protein has been shown to modulate the activity of immune cells, such as macrophages and T cells, by regulating their cytokine production and proliferation.
The potential therapeutic applications of Recombinant Human TAC1 Protein are vast and diverse. Due to its role in pain perception, TAC1 protein has been explored as a potential target for the treatment of chronic pain conditions, such as neuropathic pain and migraine. Several studies have shown that blocking the activity of TAC1 protein or its receptor can provide significant pain relief in animal models and clinical trials.
Moreover, the anti-inflammatory properties of TAC1 protein make it a promising candidate for the treatment of inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. By inhibiting the release of pro-inflammatory cytokines, TAC1 protein can potentially reduce the severity of inflammation and improve disease outcomes.
Furthermore, the role of TAC1 protein in stress response and immune function opens up possibilities for its use in the treatment of stress-related disorders and immune-related diseases. TAC1 protein has been shown to modulate the activity of immune cells in autoimmune diseases, and its administration has been found to improve symptoms in animal models of depression and anxiety.
In conclusion, Recombinant Human TAC1 Protein is a small neuropeptide with diverse physiological functions and potential therapeutic applications. Its structure, activity, and role in various physiological processes make it a promising target for the development of novel treatments for pain, inflammation, stress, and immune-related disorders. Further research and clinical trials are needed to fully understand the potential
Reviews
There are no reviews yet.
Your email address will not be published. Required fields are marked *
Your review *
Name *
Email *
Save my name, email, and website in this browser for the next time I comment.
Related products
Send us a message from the form below
First name
Last name
Email address
Lab / Company
Phone number
Message
send
Your cart is currently empty.