Recombinant Mouse APCS Protein, N-His

Description of Recombinant Mouse APCS Protein, N-His

Introduction to Recombinant Mouse APCS Protein

Recombinant Mouse APCS Protein, also known as recombinant mouse serum amyloid P component (SAP), is a protein that plays a crucial role in the body’s immune response. This protein is produced through genetic engineering techniques, making it a highly pure and specific form of the naturally occurring protein. It has a wide range of applications in the field of biomedical research and drug development, due to its unique structure and function.

Structure of Recombinant Mouse APCS Protein

The recombinant mouse APCS protein is a 25 kDa glycoprotein that is composed of 227 amino acids. It belongs to the pentraxin family of proteins, which are characterized by their pentameric structure. The protein is made up of five identical subunits, each containing a conserved lectin-like domain and a C-terminal pentraxin domain. These domains are responsible for the protein’s ability to bind to various ligands and mediate immune responses.

The lectin-like domain of the recombinant mouse APCS protein is highly conserved and is responsible for its calcium-dependent binding to carbohydrates and other ligands. This domain is also involved in the recognition and binding of pathogens, leading to their clearance from the body. The C-terminal pentraxin domain, on the other hand, is responsible for the protein’s assembly into a pentameric structure and its binding to other proteins, such as C-reactive protein and fibrinogen.

Activity of Recombinant Mouse APCS Protein

The recombinant mouse APCS protein has multiple functions in the body’s immune response. One of its main activities is its role in opsonization, which is the process of coating pathogens with antibodies or other proteins to enhance their recognition and clearance by immune cells. The protein achieves this by binding to the surface of pathogens, facilitating their recognition by macrophages and other phagocytic cells. This process is crucial for the body’s defense against infections.

In addition to its role in opsonization, the recombinant mouse APCS protein also has anti-inflammatory properties. It can bind to and neutralize pro-inflammatory molecules, such as histones and lipopolysaccharides, which are released during infections or tissue damage. This helps to reduce inflammation and prevent tissue damage, promoting tissue repair and healing.

Applications of Recombinant Mouse APCS Protein

Due to its unique structure and activity, recombinant mouse APCS protein has a wide range of applications in biomedical research and drug development. One of its main applications is in the study of immune responses and inflammatory diseases. The protein can be used as a tool to study the mechanisms of opsonization and inflammation, as well as to develop new therapies for diseases such as sepsis and autoimmune disorders.

The recombinant mouse APCS protein also has potential applications in the development of vaccines and immunotherapies. Its ability to bind to pathogens and induce immune responses makes it a promising candidate for vaccine adjuvants. It can also be used as a therapeutic agent to enhance the body’s immune response against cancer cells.

In conclusion, recombinant mouse APCS protein is a highly valuable protein with a unique structure and diverse functions. Its ability to bind to various ligands and modulate immune responses makes it an important tool in biomedical research and a potential candidate for the development of new therapies. Further studies on this protein and its interactions with other molecules will continue to uncover its potential applications in the field of medicine.