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Brand: ProteoGenix

TNFa / TNF-alpha, N-His, recombinant protein

Host species:
Mammalian cells
Origin species:
Homo sapiens (Human)
Molecular weight:
25.65 kDa

$380.00

100ug + 380 loyalty points
His Val77–Leu233
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SDS-PAGE for TNFa / TNF-alpha, N-His, recombinant protein
Etanercept Biosimilar - Anti-TNF mAb binds to TNFa / TNF-alpha, N-His, recombinant protein in indirect ELISA Assay

TNFa / TNF-alpha, N-His, recombinant protein

Product name TNFa / TNF-alpha, N-His, recombinant protein
Origin species Homo sapiens (Human)
Expression system Eukaryotic expression
Molecular weight 25.65 kDa
Protein delivered with Tag? N-terminal His Tag
Purity estimated >90% as determined by SDS-PAGE
Buffer PBS, pH7.5
Delivery condition Dry Ice
Storage condition 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand ProteoGenix
Host species Mammalian cells
Fragment Type Val77-Leu233
Protein Accession P01375
Aliases /Synonyms cachexin, cachectin
Reference PX-P5961
Note For research use only
Background information Array
Molecular Constructor
His Val77–Leu233

General information on TNFa / TNF-alpha, N-His, recombinant protein

TNF-Alpha: Cytokine Protein

TNF-alpha, also known as tumor necrosis factor-alpha, is a cytokine protein produced mainly by macrophages and other white blood cells. It is involved in the regulation of immune responses, inflammation, and cell death. TNF-alpha binds to two receptors, TNFR1 and TNFR2, which are present on the surface of many cell types. Binding to TNFR1 activates the pro-inflammatory signals, while binding to TNFR2 leads to cell death.

TNF-Alpha: Antibody-Drug Target

TNF-alpha is a target for antibody-drugs used to treat autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn’s disease. These drugs are monoclonal antibodies that bind to TNF-alpha and inhibit its activity, thus reducing inflammation and preventing tissue damage. Infliximab and adalimumab are two of the most commonly used TNF-alpha inhibitors.

TNF-Alpha: Application

TNF-alpha has also been studied for its potential therapeutic applications. It has been used in cancer therapy to induce apoptosis in tumor cells, and it has been studied as a potential treatment for HIV infection.

SDS-PAGE for TNFa / TNF-alpha, N-His, recombinant protein

SDS-PAGE for TNFa / TNF-alpha, N-His, recombinant protein

TNFa / TNF-alpha, N-His, recombinant protein on SDS-PAGE under reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is superior than 90 %.

Etanercept Biosimilar - Anti-TNF mAb binds to TNFa / TNF-alpha, N-His, recombinant protein in indirect ELISA Assay

Etanercept Biosimilar - Anti-TNF mAb binds to TNFa / TNF-alpha, N-His, recombinant protein in indirect ELISA Assay

Immobilized TNFa / TNF-alpha, N-His, recombinant protein (cat. No.PX-P5961) at 0.5µg/mL (100µL/well) can bind to Etanercept Biosimilar - Anti-TNF mAb (cat. No.PX-TA1015) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450

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