High-affinity, blocking antibodies — guaranteed

 

Cut straight to human antibodies

In therapeutic development, fully human antibodies are your safest bet for regulatory approval by FDA or EMEA. They reduce immunogenicity and adverse reactions in patients. With four distinct human antibody generation platforms (phage display, single B cell screening, hybridoma development, de novo antibody generation), we guarantee fully human antibodies for virtually any antigen.
 

Strategy you can trust, experts you can count on

Having the right platforms is important. But pairing them with top scientific minds is what truly makes the difference. At ProteoGenix, your project is handled by PhD-level experts or seasoned professionals with years of experience in antibody development. Their goal: design the most effective strategy from the start — so you can move faster and with confidence.
 

Time is everything — save months

At ProteoGenix, our proprietary phage display platforms combined with the industry’s largest panel of high-diversity human antibody libraries—naïve or immune—allow us to deliver high-affinity sequences in just 1 month.
 

Hit the target with nanomolar to picomolar affinity (10-9M to 10-12M)

High-affinity antibodies are crucial for optimizing therapeutic efficacy and minimizing side effects. At ProteoGenix, we isolate these powerful blocking antibodies through:

  • Phage display with our exclusive human libraries (naïve, immune, autoimmune, cancer, COVID-19)
  • Single B cell sorting from humanized mice

 

Risk-free discovery with our “No Win – No Fee” guarantee

If we don’t deliver binders, you don’t pay 100% of the service — it’s that simple. This isn’t just a promise, it’s our commitment to your success.
 

100% Royalty-Free. 100% Yours.

At ProteoGenix, you retain full ownership of your results. No licensing fees.

Tackling your toughest antibody challenges — with strategy and precision

At ProteoGenix, we combine the power of AI-driven discovery, expert wet-lab execution, and one of the most diverse antibody generation platforms on the market. This unique synergy enables us to take on even your most complex R&D challenges with confidence.
We’ve already supported our clients on demanding scientific projects, such as:

  • Generating antibodies against membrane proteins (e.g., GPCRs, peptide-MHC complexes)
  • Developing antibodies targeting highly conserved antigens (e.g., cytokines, interleukins)
  • Isolating antibodies against low-expression or cryptic antigens (e.g., tumor neoantigens)
  • Addressing fast-mutating targets (e.g., COVID-19 variants)
  • Targeting hard-to-reach compartments (e.g., CNS antigens)

These are just a few examples of the scientifically complex projects where we delivered high-quality monoclonal antibodies. But we also support clients facing more operational constraints, including:

  • Tight turnaround times
  • Limited project budgets
  • Toxic or weakly immunogenic targets
  • Animal-free antibody generation
  • Optimized developability for downstream success

For each case, our experts design tailor-made strategies to align with your scientific goals and technical requirements.
Got a project in mind? Let’s talk strategy.

More than a service – a partnership for success

At ProteoGenix, we don’t just develop antibodies—we ensure your success.

    • Innovation at your service: Our technology watch team is dedicated to your project’s success. If standard methods don’t yield the expected results, we go the extra mile—researching and testing new protocols tailored to your needs.
    • Expert guidance: Your project is overseen by highly skilled specialists—most of our account managers hold PhDs or have extensive experience in antibody development. They don’t just monitor your project; they actively advise you at every step.
    • The right strategy for your goals: From antibody discovery to bioproduction, we provide the most suitable approach based on your objectives, constraints, and final application—ensuring optimal results.
    • Minimize risk even more: For complex projects, we offer a customized backup strategy that can be activated on demand. Don’t gamble on uncertain outcomes—choose ProteoGenix for guaranteed success!

Don’t gamble on uncertain outcomes—choose ProteoGenix for guaranteed success!

Trusted by leading biotech and academic institutions

  • ProteoGenix supported Trident Biopharm Solutions in developing a cocktail of neutralizing antibodies against COVID-19 variants.

  • ProteoGenix collaborated with Isar Bioscience to generate an anti-TREM-2 antibody for a novel Alzheimer’s therapy.

  • ProteoGenix assisted Brown University in discovering two anti-malaria antibodies using its proprietary platforms.

What our clients say

We have been working together with ProteoGenix since 2020. Using phage display, they helped our team to develop several antibodies with effective blocking effects. We are pleased with their services and look forward to continue working together with them as we advance our research and bring the biologics to the clinical stage.

I requested ProteoGenix’s services for the generation of neutralizing anti-COVID-19 antibodies by Phage-Display. They designed an optimised strategy for this purpose which led to great results, with 4 antibodies identified as cross-reactive and neutralizing against all the current variants of concerns. During the whole project, Proteogenix strived to ensure the best quality of their final deliverables, especially by including additional screenings against emerging variants as the pandemics evolved. Their proactivity was key to obtain promising and relevant blocking antibodies in only a few months. I highly recommend them for both their level of expertise and the personalised service they offer.

We are developing a novel immunotherapy and needed a highly potent monoclonal antibody. Currently the development of a novel antibody requires lengthy and expensive humanization process. We thus decided to screen for binders via phage display screening instead using a human library. Proteogenix proposed just that. We provided our purified target antigen and in only one month several high affinity binders were obtained. We were able to quickly clone and produce a monoclonal antibody from the sequences provided. What should have taken 6 to 8 months was done in 2 for a fraction of the cost and for an equivalent quality.

I requested ProteoGenix’s services for the generation of antibodies against a malarial protein by phage display. Their naive human library, which is comprised of 368 donors, is a unique resource which was one of the criteria I used to select their company. They optimized their standard screening strategy to be able to identify two specific clones, that they then expressed with very high yields in their proprietary XtenCHOTM cell line. I highly appreciated their level of expertise and their commitment to go beyond expectations, and I would recommend them for their reactivity and the high quality of their services.

Selected publications and patents

E Vidal-Calvo et al., Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate. Nature Communications 15, 7553 (2024).
https://doi.org/10.1038/s41467-024-51781-0

H Cerutti et al., Large scale production and characterization of SARS-CoV-2 whole antigen for serological test development. J Clin Lab Anal 35, (4) 23735 (2021).
https://doi.org/10.1002/jcla.23735

M Pitaro et al., Development of a recombinant human IgG1 monoclonal antibody against the TRBV5-1 segment of the T cell receptor for the treatment of mature T cell neoplasms. Front Immunol 15, 1520103 (2024).
https://doi.org/10.3389/fimmu.2024.1520103

Christlmeier M, et al. Human anti-trem2 antibody for treating neurodegenerative disorders. WO2024160736A1. 2024 Aug 8.
https://patents.google.com/patent/WO2024160736A1/en

You can learn more on this project here.

El Mazouari K. Human-like target-binding proteins. WO2023161448A1. 2023 Aug 31.
https://patents.google.com/patent/WO2023161448A1/en

Maione F, et al. Novel interleukin-17a (il-17a)-derived peptide and neutralizing antibody (ab17-ipl-1). WO2024028436A1. 2024 Feb 8.
https://patents.google.com/patent/WO2024028436A1/en

FAQ – Your questions about our therapeutic antibody discovery services answered

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