Aldafermin ELISA Kit

Description of Aldafermin ELISA Kit

Introduction

The Aldafermin ELISA Kit is a highly sensitive and specific assay designed for the detection and quantification of Aldafermin, also known as NGM282, in biological samples. This kit is a valuable tool for both research and therapeutic purposes, as it provides a reliable and accurate method for measuring the levels of Aldafermin in various biological samples.

Structure of Aldafermin

Aldafermin is a recombinant human protein that belongs to the family of fibroblast growth factors (FGFs). It is a truncated form of FGF19, which is a hormone-like protein that plays a crucial role in the regulation of bile acid synthesis and glucose metabolism. Aldafermin consists of 172 amino acids and has a molecular weight of approximately 20 kDa.

Activity of Aldafermin

Aldafermin has been identified as a potent and selective agonist of FGF19 receptor complex, which is composed of FGF receptor 4 (FGFR4) and β-Klotho. This receptor complex is predominantly expressed in the liver and plays a crucial role in regulating bile acid synthesis and glucose metabolism. Aldafermin binds to the receptor complex and activates downstream signaling pathways, leading to the inhibition of bile acid synthesis and improvement of glucose metabolism.

Application of Aldafermin ELISA Kit

The Aldafermin ELISA Kit has multiple applications in both research and therapeutic settings. Some of the key applications of this kit are described below:

Therapeutic Target Aldafermin is currently being investigated as a potential therapeutic target for the treatment of non-alcoholic steatohepatitis (NASH) and other liver diseases. NASH is a progressive form of non-alcoholic fatty liver disease (NAFLD) that can lead to liver fibrosis, cirrhosis, and even liver failure. Preclinical and clinical studies have shown that Aldafermin can improve liver function, reduce liver fat, and improve liver histology in patients with NASH. The Aldafermin ELISA Kit can be used to monitor the levels of Aldafermin in patients undergoing treatment, and to assess the efficacy of Aldafermin as a therapeutic target.

Research Use

The Aldafermin ELISA Kit is also a valuable tool for research purposes. It can be used to measure the levels of Aldafermin in different biological samples, such as serum, plasma, and tissue homogenates. This can help researchers to understand the role of Aldafermin in various physiological and pathological processes. For example, the kit can be used to study the regulation of bile acid synthesis and glucose metabolism by Aldafermin, as well as its potential role in other liver diseases.

Biomarker Discovery

Aldafermin has been identified as a potential biomarker for NASH and other liver diseases. The Aldafermin ELISA Kit can be used to measure the levels of Aldafermin in patient samples and to identify potential correlations between Aldafermin levels and disease progression. This can help in the development of new diagnostic and prognostic tools for liver diseases.

Pharmacokinetic Studies

The Aldafermin ELISA Kit can also be used in pharmacokinetic studies to measure the levels of Aldafermin in different biological samples after administration of the drug. This can help in understanding the absorption, distribution, metabolism, and excretion of Aldafermin in the body, which is crucial for the development of safe and effective dosing regimens.

Conclusion

The Aldafermin ELISA Kit is a highly sensitive and specific assay that provides a reliable and accurate method for measuring the levels of Aldafermin in biological samples. It has multiple applications in both research and therapeutic settings, making it a valuable tool for