No services found
No Products found
100ug, 1MG
IgG1, kappa
ProteoGenix
Primary Antibodies
Monoclonal Antibody
Mammalian cells
Elisa, WB
Bemarituzumab is a humanized monoclonal antibody targeting the human fibroblast growth factor receptor 2b (FGFR2b). This humanized glycosylated biosimilar belong to the family of immunoglobulin G1- type. It blocks FGF ligand binding to the receptor, which causes the inhibition of downstream signaling pathways and promotes Antibody-dependent cell-mediated cytotoxicity (ADCC). Bemarituzumab induces receptor internalization and degradation.
FGFR2b is an isoform of fibroblast growth factor receptors. They are four signaling tyrosine kinase FGF receptors mediating interactions between cytosolic environment and mesenchyme. Activated FGFRs can phosphorylate tyrosine residues which are mediating specifically interaction with cytosolic adaptor proteins. FGFR2b receptor is overexpressed in 30% of HER2-negative Gastric and Gastroesophageal Cancers. Bemarituzumab is designed to target these specific cancer subtypes, which are using the FGF/FGFR pathway to promote transformation and proliferation of cells into tumors and to promote angiogenesis.
Bemarituzumab biosimilar is a humanized antibody based on cross Mab technology. It is produced in mammalian cell line (Chinese Hamster Ovary -CHO) using a recombinant DNA technology. Proteogenix offer a product for research use only, not suitable for clinical or therapeutic use.
Bemarituzumab Biosimilar - Anti-FGFR2 mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.
Reviews
There are no reviews yet.
Your email address will not be published. Required fields are marked *
In which application did you use the antibody? * WB ELISA Sandwich ELISA IF IHC IP FC other
Did it work in your application? * Yes No
Your review *
Name *
Email *
Save my name, email, and website in this browser for the next time I comment.
Related products
Send us a message from the form below
First name
Last name
Email address
Lab / Company
Phone number
Message
send
Your cart is currently empty.