Store at - 20℃ to -80℃.
It is recommended that the protein be aliquoted for optimal storage.
Brand
ProteoGenix
Host species
Mammalian cells
Fragment Type
Met1~Asn242
Aliases /Synonyms
CD28LG, CD28LG1, LAB7
Reference
PX-P4090
Note
For research use only
Description of CD80 Recombinant Protein
General information on CD80 Recombinant Protein:
Cluster of Differentiation 80, also known as B7-1, is a member of the cell surface immunoglobulin superfamily. It is expressed on the surface of antigen presenting cells, including activated B cells, macrophages and dendritic cells. CD80 plays a fundamental but different role in the activation of T cells. B7-1 / CD80 and B7-2 / CD86 and its CD28 and CTLA4 receptors constitute one of the main co-stimulatory pathways that regulate the response of T and B cells. CD80 is mainly expressed on the surface of antigen presenting cells, including activated B cells, macrophages and dendritic cells. Although CTLA-4 and CD28 can bind to the same ligand, CTLA-4 binds B7-1 and B7-2 with an affinity 20-100 times greater than CD28 and participates in the negative regulation of immune responses. Therefore, CD80 is considered a promising therapeutic target for autoimmune diseases and various types of cancer.
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