Efungumab Biosimilar – Anti-HSP91 homolog mAb – Research Grade

Description of Efungumab Biosimilar - Anti-HSP91 homolog mAb - Research Grade

Introduction

Efungumab Biosimilar, also known as Anti-HSP91 homolog monoclonal antibody (mAb), is a research grade antibody that has shown promising results in the treatment of various diseases. This article will provide a detailed description of the structure, activity, and potential applications of Efungumab Biosimilar.

Structure of Efungumab Biosimilar

Efungumab Biosimilar is a monoclonal antibody that specifically targets the heat shock protein 90 (HSP90) homolog, a protein involved in several cellular processes such as protein folding, cell cycle regulation, and cell signaling. It is a recombinant protein produced in a mammalian cell expression system and has a molecular weight of approximately 150 kDa. The antibody has a typical immunoglobulin G (IgG) structure, with two heavy chains and two light chains joined by disulfide bonds.

Activity of Efungumab Biosimilar

Efungumab Biosimilar works by binding to the HSP90 homolog, inhibiting its activity and leading to the degradation of client proteins that depend on HSP90 for their stability. This results in the disruption of various cellular processes and ultimately leads to cell death. Additionally, Efungumab Biosimilar has been shown to induce an immune response against tumor cells, making it a potential therapeutic agent for cancer treatment.

Applications of Efungumab Biosimilar

Efungumab Biosimilar has shown promising results in preclinical studies as a potential treatment for various diseases. Its ability to inhibit the activity of HSP90 homolog makes it a potential therapeutic target for cancer, as HSP90 is overexpressed in many types of cancer cells. In addition, Efungumab Biosimilar has also shown efficacy in treating autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, where HSP90 is involved in the regulation of immune responses.

Furthermore, Efungumab Biosimilar has been studied as a potential treatment for infectious diseases. HSP90 is known to play a role in the replication of certain viruses, and by inhibiting its activity, Efungumab Biosimilar could potentially inhibit viral replication and reduce the severity of viral infections.

Conclusion

In conclusion, Efungumab Biosimilar is a research grade antibody that specifically targets the HSP90 homolog and has shown promising results in preclinical studies as a potential treatment for various diseases. Its unique mechanism of action and potential for treating a wide range of diseases make it a promising therapeutic agent. Further studies and clinical trials are needed to fully understand the efficacy and safety of Efungumab Biosimilar, but it holds great potential for improving the treatment of various diseases.

SDS-PAGE for Efungumab Biosimilar - Anti-HSP91 homolog mAb

Efungumab Biosimilar - Anti-HSP91 homolog mAb, on SDS-PAGE under reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the protein antibody is superior than 90 %.