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View ProductsEGFR / ERBB1 / HER1, C-His, recombinant protein
| size | 100ug |
|---|---|
| Brand | ProteoGenix |
| Product type | Recombinant Proteins |
| Host Species | Mammalian cells |
| Applications | Elisa, WB |
| Product name | EGFR / ERBB1 / HER1, C-His, recombinant protein |
|---|---|
| Origin species | Homo sapiens (Human) |
| Expression system | Eukaryotic expression |
| Molecular weight | 134.29 kDa |
| Protein delivered with Tag? | C-terminal His Tag |
| Purity estimated | >90% as determined by SDS-PAGE |
| Buffer | PBS, pH7.5 |
| Delivery condition | Dry Ice |
| Delivery lead time in business days | 3-5 days if in stock; 3-5 weeks if production needed |
| Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
| Brand | ProteoGenix |
| Host species | Mammalian cells |
| Applications | ELISA,WB |
| Fragment Type | Met1-Ser645 |
| Protein Accession | P00533 |
| Reference | PX-P5701 |
| Note | For research use only. |
Description of EGFR / ERBB1 / HER1, C-His, recombinant protein
General information on EGFR / ERBB1 / HER1, C-His, recombinant protein
Structure
EGFR (Epidermal Growth Factor Receptor, also known as ERBB1 or HER1) is a transmembrane receptor tyrosine kinase, composed of an extracellular ligand binding domain, a transmembrane region and an intracellular tyrosine kinase domain.
Activity
EGFR is activated by binding of its ligand, epidermal growth factor (EGF). This binding causes a conformational change in the receptor, leading to autophosphorylation of its tyrosine kinase domain and the initiation of downstream signaling pathways.
Application
EGFR is involved in a variety of cellular processes, including cell proliferation, differentiation, and migration. It is also a target for antibody-drug conjugates, which are used in the treatment of various cancers.
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