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Human B-Gal Recombinant Protein

Reference:
size

100ug, 50ug
Brand

ProteoGenix
Product type

Recombinant Proteins
Host Species

Mammalian cells
Applications

Elisa, WB
Tags:
Specification
Documents
Publications
Reviews
Product nameHuman B-Gal Recombinant Protein
Uniprot IDP16278
Uniprot linkhttp://www.uniprot.org/uniprot/P16278
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
SequenceMLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHW
Molecular weight74.66KDa
Purity estimated70%
BufferPBS, pH 7.5
FormFrozen
Delivery conditionDry Ice
Delivery lead time in business days10-25
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesMammalian cells
Fragment TypePartial
Protein AccessionAAA51819.1
Spec:Entrez GeneID2720
Spec:NCBI Gene AliasesELNR1, EBP, MPS4B
Spec:SwissProtIDP16278
NCBI ReferenceAAA51819.1
Aliases /SynonymsB-Gal, galactosidase, beta 1, beta-D-galactosidase precursor, Beta-galactosidase, GLB1, ELNR1, Acid beta-galactosidase, Lactase, Elastin receptor 1
ReferencePX-P2051
NoteFor research use only
Datasheet Download
MSDS Download

Publication

  • 1: Gao SG, Zeng C, Li LJ, Luo W, Zhang FJ, Tian J, Cheng C, Tu M, Xiong YL, Jiang_x000D_ W, Xu M, Lei GH. Correlation between senescence-associated beta-galactosidase_x000D_ expression in articular cartilage and disease severity of patients with knee_x000D_ osteoarthritis. Int J Rheum Dis. 2016 Mar;19(3):226-32. doi:_x000D_ 10.1111/1756-185X.12096. Epub 2013 Jun 3. PubMed PMID: 26112901.
    • _x000D_ _x000D_ _x000D_
  • 2: Bidchol AM, Dalal A, Trivedi R, Shukla A, Nampoothiri S, Sankar VH, Danda S,_x000D_ Gupta N, Kabra M, Hebbar SA, Bhat RY, Matta D, Ekbote AV, Puri RD, Phadke SR,_x000D_ Gowrishankar K, Aggarwal S, Ranganath P, Sharda S, Kamate M, Datar CA, Bhat K,_x000D_ Kamath N, Shah H, Krishna S, Gopinath PM, Verma IC, Nagarajaram HA, Satyamoorthy _x000D_ K, Girisha KM. Recurrent and novel GLB1 mutations in India. Gene. 2015 Aug_x000D_ 10;567(2):173-81. doi: 10.1016/j.gene.2015.04.078. Epub 2015 Apr 30. PubMed PMID:_x000D_ 25936995.
    • _x000D_ _x000D_ _x000D_
  • 3: Regier DS, Tifft CJ. GLB1-Related Disorders. 2013 Oct 17. In: Pagon RA, Adam_x000D_ MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford_x000D_ HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA):_x000D_ University of Washington, Seattle; 1993-2017. Available from_x000D_ http://www.ncbi.nlm.nih.gov/books/NBK164500/_x000D_ PubMed PMID: 24156116.
    • _x000D_ _x000D_ _x000D_
  • 4: Waszkiewicz N, Szajda SD, Waszkiewicz M, Wojtulewska-Supron A, Szulc A, Kępka _x000D_ A, Chojnowska S, Dadan J, Ładny JR, Zwierz K, Zalewska-Szajda B. The activity of _x000D_ serum beta-galactosidase in colon cancer patients with a history of alcohol and_x000D_ nicotine dependence: preliminary data. Postepy Hig Med Dosw (Online). 2013 Aug_x000D_ 26;67:896-900. PubMed PMID: 24018455.
    • _x000D_ _x000D_ _x000D_
  • 5: Alexandraki KI, Munayem Khan M, Chahal HS, Dalantaeva NS, Trivellin G, Berney _x000D_ DM, Caron P, Popovic V, Pfeifer M, Jordan S, Korbonits M, Grossman AB._x000D_ Oncogene-induced senescence in pituitary adenomas and carcinomas. Hormones_x000D_ (Athens). 2012 Jul-Sep;11(3):297-307. PubMed PMID: 22908062.
    • _x000D_ _x000D_ _x000D_
  • 6: Celtikçi B, Aydın Hİ, Sivri S, Sönmez M, Topçu M, Ozkara HA. Four novel_x000D_ mutations in the β-galactosidase gene identified in infantile type of GM1_x000D_ gangliosidosis. Clin Biochem. 2012 May;45(7-8):571-4. doi:_x000D_ 10.1016/j.clinbiochem.2011.12.019. Epub 2012 Jan 3. PubMed PMID: 22234367.
    • _x000D_ _x000D_ _x000D_
  • 7: Skeie JM, Hernandez J, Hinek A, Mullins RF. Molecular responses of choroidal_x000D_ endothelial cells to elastin derived peptides through the elastin-binding protein_x000D_ (GLB1). Matrix Biol. 2012 Mar;31(2):113-9. doi: 10.1016/j.matbio.2011.11.003._x000D_ Epub 2011 Dec 2. PubMed PMID: 22178079; PubMed Central PMCID: PMC3288713.
    • _x000D_ _x000D_ _x000D_
  • 8: Ohto U, Usui K, Ochi T, Yuki K, Satow Y, Shimizu T. Crystal structure of human_x000D_ β-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases. J_x000D_ Biol Chem. 2012 Jan 13;287(3):1801-12. doi: 10.1074/jbc.M111.293795. Epub 2011_x000D_ Nov 28. PubMed PMID: 22128166; PubMed Central PMCID: PMC3265862.
    • _x000D_ _x000D_ _x000D_
  • 9: Fantur KM, Wrodnigg TM, Stütz AE, Pabst BM, Paschke E. Fluorous iminoalditols _x000D_ act as effective pharmacological chaperones against gene products from GLB₁_x000D_ alleles causing GM1-gangliosidosis and Morquio B disease. J Inherit Metab Dis._x000D_ 2012 May;35(3):495-503. doi: 10.1007/s10545-011-9409-2. Epub 2011 Oct 28. PubMed _x000D_ PMID: 22033734.
    • _x000D_ _x000D_ _x000D_
  • 10: Murphy BA, Bunda S, Mitts T, Hinek A. The hyperthermia-enhanced association_x000D_ between tropoelastin and its 67-kDa chaperone results in better deposition of_x000D_ elastic fibers. J Biol Chem. 2010 Dec 17;285(51):40282-93. doi:_x000D_ 10.1074/jbc.M110.169656. Epub 2010 Oct 13. PubMed PMID: 20947500; PubMed Central _x000D_ PMCID: PMC3001008.
    • _x000D_ _x000D_ _x000D_
  • 11: Yang CF, Wu JY, Tsai FJ. Three novel beta-galactosidase gene mutations in Han_x000D_ Chinese patients with GM1 gangliosidosis are correlated with disease severity. J _x000D_ Biomed Sci. 2010 Sep 30;17:79. doi: 10.1186/1423-0127-17-79. PubMed PMID:_x000D_ 20920281; PubMed Central PMCID: PMC2959015.
    • _x000D_ _x000D_ _x000D_
  • 12: Li L, Higaki K, Ninomiya H, Luan Z, Iida M, Ogawa S, Suzuki Y, Ohno K, Nanba _x000D_ E. Chemical chaperone therapy: luciferase assay for screening of β-galactosidase _x000D_ mutations. Mol Genet Metab. 2010 Dec;101(4):364-9. doi:_x000D_ 10.1016/j.ymgme.2010.08.012. Epub 2010 Aug 18. PubMed PMID: 20826101.
    • _x000D_ _x000D_ _x000D_
  • 13: Hofer D, Paul K, Fantur K, Beck M, Roubergue A, Vellodi A, Poorthuis BJ,_x000D_ Michelakakis H, Plecko B, Paschke E. Phenotype determining alleles in GM1_x000D_ gangliosidosis patients bearing novel GLB1 mutations. Clin Genet. 2010_x000D_ Sep;78(3):236-46. doi: 10.1111/j.1399-0004.2010.01379.x. Epub 2010 Feb 11. PubMed_x000D_ PMID: 20175788.
    • _x000D_ _x000D_ _x000D_
  • 14: Antonicelli F, Bellon G, Lorimier S, Hornebeck W. Role of the elastin_x000D_ receptor complex (S-Gal/Cath-A/Neu-1) in skin repair and regeneration. Wound_x000D_ Repair Regen. 2009 Sep-Oct;17(5):631-8. doi: 10.1111/j.1524-475X.2009.00525.x._x000D_ PubMed PMID: 19769716.
    • _x000D_ _x000D_ _x000D_
  • 15: Hofer D, Paul K, Fantur K, Beck M, Bürger F, Caillaud C, Fumic K, Ledvinova_x000D_ J, Lugowska A, Michelakakis H, Radeva B, Ramaswami U, Plecko B, Paschke E. GM1_x000D_ gangliosidosis and Morquio B disease: expression analysis of missense mutations_x000D_ affecting the catalytic site of acid beta-galactosidase. Hum Mutat. 2009_x000D_ Aug;30(8):1214-21. doi: 10.1002/humu.21031. PubMed PMID: 19472408.
    • _x000D_ _x000D_ _x000D_
  • 16: Mayer FQ, Pereira Fdos S, Fensom AH, Slade C, Matte U, Giugliani R. New GLB1 _x000D_ mutation in siblings with Morquio type B disease presenting with mental_x000D_ regression. Mol Genet Metab. 2009 Mar;96(3):148. doi:_x000D_ 10.1016/j.ymgme.2008.11.159. Epub 2008 Dec 16. PubMed PMID: 19091613.

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