Name: Human FLT1 recombinant protein
SKU: PX-P6096-100
Availability: InStock

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size	100ug
Brand	ProteoGenix
Product type	Recombinant Proteins
Host Species	Mammalian cells
Applications	Elisa, WB

Recombinant Proteins VEGF - VEGFR Antibody-Drug Target ELISA WB

Product name	Human FLT1 recombinant protein
Uniprot ID	P17948
Origin species	Homo sapiens (Human)
Expression system	Eukaryotic expression
Molecular weight	37.77 kDa
Protein delivered with Tag?	C-Terminal His Tag
Purity estimated	>85% by SDS-PAGE
Buffer	0.01M PBS, pH 7.4.
Delivery condition	Dry Ice
Storage condition	4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand	ProteoGenix
Host species	Mammalian cells
Fragment Type	Met1-Ile328
Aliases /Synonyms	FLT1, Vascular endothelial Growth Factor proteins receptor 1, VEGFR1, Vascular permeability factor receptor, FRT, Tyrosine-protein kinase receptor FLT, VEGFR-1, FLT, FLT-1, Tyrosine-protein kinase FRT, Fms-like tyrosine kinase 1, Drug Target
Reference	PX-P6096
Note	For research use only

Description of Human FLT1 recombinant protein

General information on Human FLT1 recombinant protein

Human FLT1 Recombinant Protein: Structure and Activity

Human Fms-like tyrosine kinase 1 (FLT1) is a type I membrane receptor belonging to the vascular endothelial growth factor receptor (VEGFR) family. It is composed of an extracellular domain, a single transmembrane domain, and an intracellular domain. The extracellular domain of FLT1 binds to VEGF-A, VEGF-C, and VEGF-D, while the intracellular domain has tyrosine kinase activity. FLT1 is involved in the regulation of angiogenesis, vascular permeability, and cell proliferation.

FLT1 as an Antibody-Drug Target

FLT1 is an attractive target for antibody-drug conjugates (ADCs) due to its role in tumor growth and angiogenesis. ADCs are composed of an antibody linked to a cytotoxic drug. The antibody binds to the FLT1 receptor and the drug is internalized, leading to cell death. FLT1-targeted ADCs have been used in clinical trials for various types of cancer, including ovarian, gastric, and colorectal cancers.

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Human FLT1 recombinant protein