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View Productssize | 100ug |
---|---|
Brand | ProteoGenix |
Product type | Recombinant Proteins |
Host Species | Mammalian cells |
Applications | Elisa, WB |
Product name | Human PD-L2 recombinant protein |
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Uniprot ID | Q9BQ51 |
Uniprot link | https://www.uniprot.org/uniprot/Q9BQ51 |
Origin species | Homo sapiens (Human) |
Expression system | Eukaryotic expression |
Molecular weight | 23.62 kDa |
Protein delivered with Tag? | C-terminal His Tag |
Purity estimated | >85% by SDS-PAGE |
Buffer | PBS, pH7.5 |
Delivery condition | Dry Ice |
Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
Brand | ProteoGenix |
Host species | Mammalian cells |
Fragment Type | Met1-Thr220 |
Aliases /Synonyms | PDCD1 ligand 2, B7-DC, PD-L2, PDCD1LG2, PDCD1L2, PDL2, Butyrophilin B7-DC, Programmed death ligand 2, Programmed cell death 1 ligand 2, CD273, B7DC, PD-1 ligand 2 |
Reference | PX-P6014 |
Note | For research use only |
Human PD-L2 recombinant protein is a type I transmembrane glycoprotein and is a member of the B7 family of CD proteins. It consists of a single extracellular immunoglobulin-like domain, a transmembrane domain and a short cytoplasmic tail.
PD-L2 plays an important role in the regulation of immune responses by binding to its receptor PD-1 on the surface of T cells and B cells. This binding leads to the inhibition of the activation and proliferation of these cells, thus acting as an immune checkpoint protein.
Human PD-L2 recombinant protein is used in antibody-drug target therapy, where it is used to develop antibodies that can bind to PD-L2 and block the PD-L2/PD-1 interaction. This can result in the activation and proliferation of T cells and B cells, thus enhancing the immune response against cancer cells.
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