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Human Pepsin A-3(PGI) Recombinant Protein

Reference:
size

100ug, 50ug
Brand

ProteoGenix
Product type

Recombinant Proteins
Host Species

Mammalian cells
Applications

Elisa, WB
Tags:
Specification
Documents
Publications
Reviews
Product nameHuman Pepsin A-3(PGI) Recombinant Protein
Uniprot IDP0DJD8
Uniprot linkhttp://www.uniprot.org/uniprot/P0DJD8
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
SequenceMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVAGSHHHHHH
Molecular weight44.68 kDa
Purity estimated85%
BufferPBS, pH 7.5
FormFrozen
Delivery conditionDry Ice
Delivery lead time in business days5-7
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesMammalian cells
Fragment TypeFull-length
Spec:NCBI Gene AliasesPGA3
Spec:SwissProtIDP0DJD8.1
NCBI ReferenceP0DJD8
Aliases /SynonymsEC 3.4.23; EC 3.4.23.1; FLJ58952; FLJ77962; pepsin A; pepsinogen 4, group I (pepsinogen A); Pepsinogen A; pepsinogen A4; PGA3; PGA5
ReferencePX-P3000
NoteFor research use only
Datasheet Download
MSDS Download

Publication

  • 1: Mansour-Ghanaei F, Joukar F, Rajpout Y, Hasandokht T. Screening of_x000D_ precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter_x000D_ pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in_x000D_ Guilan Province, north of Iran. Asian Pac J Cancer Prev. 2014;15(18):7635-8._x000D_ PubMed PMID: 25292040.
    • _x000D_ _x000D_ _x000D_
  • 2: Shafaghi A, Mansour-Ghanaei F, Joukar F, Sharafkhah M, Mesbah A, Askari K,_x000D_ Geranmayeh S, Mehrvarz A, Souti F, Sokhanvar H, Fakhrieh S, Aminian K,_x000D_ Yousefi-Mashhour M, Khosh-Sorur M, Rasoulian J. Serum gastrin and the pepsinogen _x000D_ I/II ratio as markers for diagnosis of premalignant gastric lesions. Asian Pac J _x000D_ Cancer Prev. 2013;14(6):3931-6. PubMed PMID: 23886209.
    • _x000D_ _x000D_ _x000D_
  • 3: Abe Y, Iijima K, Koike T, Asanuma K, Imatani A, Ohara S, Shimosegawa T._x000D_ Barrett's esophagus is characterized by the absence of Helicobacter pylori_x000D_ infection and high levels of serum pepsinogen I concentration in Japan. J_x000D_ Gastroenterol Hepatol. 2009 Jan;24(1):129-34. doi:_x000D_ 10.1111/j.1440-1746.2008.05691.x. PubMed PMID: 19196398.
    • _x000D_ _x000D_ _x000D_
  • 4: Korsnes L, Gedde-Dahl T Jr. Genetics of pepsinogen I. Ann Hum Genet. 1980_x000D_ Jan;43(3):199-212. PubMed PMID: 6767433.
    • _x000D_ _x000D_ _x000D_
  • 5: Tu H, Sun L, Dong X, Gong Y, Xu Q, Jing J, Long Q, Flanders WD, Bostick RM,_x000D_ Yuan Y. Temporal changes in serum biomarkers and risk for progression of gastric _x000D_ precancerous lesions: a longitudinal study. Int J Cancer. 2015 Jan_x000D_ 15;136(2):425-34. doi: 10.1002/ijc.29005. Epub 2014 Jun 19. PubMed PMID:_x000D_ 24895149; PubMed Central PMCID: PMC4354768.
    • _x000D_ _x000D_ _x000D_
  • 6: Peitz U, Wex T, Vieth M, Stolte M, Willich S, Labenz J, Jaspersen D, Lind T,_x000D_ Malfertheiner P. Correlation of serum pepsinogens and gastrin-17 with atrophic_x000D_ gastritis in gastroesophageal reflux patients: a matched-pairs study. J_x000D_ Gastroenterol Hepatol. 2011 Jan;26(1):82-9. doi:_x000D_ 10.1111/j.1440-1746.2010.06413.x. PubMed PMID: 21175799.
    • _x000D_ _x000D_ _x000D_
  • 7: Kamangar F, Diaw L, Wei WQ, Abnet CC, Wang GQ, Roth MJ, Liu B, Lu N, Giffen C,_x000D_ Qiao YL, Dawsey SM. Serum pepsinogens and risk of esophageal squamous dysplasia. _x000D_ Int J Cancer. 2009 Jan 15;124(2):456-60. doi: 10.1002/ijc.23918. PubMed PMID:_x000D_ 18844222; PubMed Central PMCID: PMC2605159.
    • _x000D_ _x000D_ _x000D_
  • 8: Shiotani A, Iishi H, Uedo N, Kumamoto M, Nakae Y, Ishiguro S, Tatsuta M,_x000D_ Graham DY. Histologic and serum risk markers for noncardia early gastric cancer. _x000D_ Int J Cancer. 2005 Jun 20;115(3):463-9. PubMed PMID: 15688378.
    • _x000D_ _x000D_ _x000D_
  • 9: Terasawa T, Nishida H, Kato K, Miyashiro I, Yoshikawa T, Takaku R, Hamashima_x000D_ C. Prediction of gastric cancer development by serum pepsinogen test and_x000D_ Helicobacter pylori seropositivity in Eastern Asians: a systematic review and_x000D_ meta-analysis. PLoS One. 2014 Oct 14;9(10):e109783. doi:_x000D_ 10.1371/journal.pone.0109783. eCollection 2014. Review. PubMed PMID: 25314140;_x000D_ PubMed Central PMCID: PMC4196955.
    • _x000D_ _x000D_ _x000D_
  • 10: Zhang XM, Li JX, Zhang GY, Li XH, Gu H. The value of serum pepsinogen levels _x000D_ for the diagnosis of gastric diseases in Chinese Han people in midsouth China._x000D_ BMC Gastroenterol. 2014 Jan 3;14:3. doi: 10.1186/1471-230X-14-3. PubMed PMID:_x000D_ 24383519; PubMed Central PMCID: PMC3893538.
    • _x000D_ _x000D_ _x000D_
  • 11: Huang M, Tang AG, Mu S, Yang JJ, Xiang ZY, Liu B, Yang JJ. Serum pepsinogen_x000D_ reference intervals in apparently healthy Chinese population with latex enhanced _x000D_ turbidimetric immunoassay. J Clin Pathol. 2014 Apr;67(4):350-4. doi:_x000D_ 10.1136/jclinpath-2013-201942. Epub 2013 Oct 29. PubMed PMID: 24170207.
    • _x000D_ _x000D_ _x000D_
  • 12: Kutsuma A, Oshida H, Suwa K, Nakajima K. A possible association of low_x000D_ pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men._x000D_ Clin Biochem. 2014 Jan;47(1-2):126-8. doi: 10.1016/j.clinbiochem.2013.10.003._x000D_ Epub 2013 Oct 11. PubMed PMID: 24125879.
    • _x000D_ _x000D_ _x000D_
  • 13: Li P, He C, Sun L, Dong N, Yuan Y. Pepsinogen I and II expressions in situ_x000D_ and their correlations with serum pesignogen levels in gastric cancer and its_x000D_ precancerous disease. BMC Clin Pathol. 2013 Sep 2;13(1):22. doi:_x000D_ 10.1186/1472-6890-13-22. PubMed PMID: 24004680; PubMed Central PMCID: PMC3846408.
    • _x000D_ _x000D_ _x000D_
  • 14: Chae HD, Kim IH, Lee GH, Shin IH, Suh HS, Jeon CH. Gastric cancer detection_x000D_ using gastric juice pepsinogen and melanoma-associated gene RNA. Am J Clin_x000D_ Pathol. 2013 Aug;140(2):209-14. doi: 10.1309/AJCPOHXRM5IYXVOC. PubMed PMID:_x000D_ 23897256.
    • _x000D_ _x000D_ _x000D_
  • 15: Xu Q, Dong QG, Sun LP, He CY, Yuan Y. Expression of serum miR-20a-5p, let-7a,_x000D_ and miR-320a and their correlations with pepsinogen in atrophic gastritis and_x000D_ gastric cancer: a case-control study. BMC Clin Pathol. 2013 Mar 22;13:11. doi:_x000D_ 10.1186/1472-6890-13-11. PubMed PMID: 23521833; PubMed Central PMCID: PMC3635921.

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