Ifabotuzumab ELISA Kit

Description of Ifabotuzumab ELISA Kit

Introduction

The Ifabotuzumab ELISA Kit is a valuable tool for researchers and clinicians alike, providing a reliable and efficient method for detecting and quantifying Ifabotuzumab levels in biological samples. This kit is specifically designed for the detection of Ifabotuzumab, a promising therapeutic target for various types of cancer. In this article, we will discuss the structure, activity, and applications of Ifabotuzumab ELISA Kit in detail.

Structure of Ifabotuzumab

Ifabotuzumab, also known as BI 836845, is a monoclonal antibody that specifically targets the extracellular domain of the EphA3 receptor. This receptor is overexpressed in various types of cancer, including glioblastoma, melanoma, and lung cancer, making it an attractive therapeutic target. Ifabotuzumab is a humanized IgG1 antibody, consisting of two heavy chains and two light chains, with a molecular weight of approximately 150 kDa. The antibody has a high binding affinity for the EphA3 receptor, making it an effective tool for targeted therapy.

Activity of Ifabotuzumab

Ifabotuzumab works by binding to the EphA3 receptor, which is highly expressed on the surface of cancer cells. This binding inhibits the activation of the receptor, leading to the inhibition of downstream signaling pathways that promote cancer cell growth and survival. In addition, Ifabotuzumab also induces antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) mechanisms, which further enhance its anti-tumor activity. These mechanisms make Ifabotuzumab a potent and selective therapeutic agent for the treatment of cancer.

Application of Ifabotuzumab ELISA Kit

The Ifabotuzumab ELISA Kit is a highly sensitive and specific assay that allows for the quantification of Ifabotuzumab levels in various biological samples, such as serum, plasma, and cell culture supernatants. This kit is particularly useful for monitoring Ifabotuzumab levels in patients undergoing treatment with this antibody, as well as for preclinical studies evaluating the efficacy of Ifabotuzumab in different cancer models. The Ifabotuzumab ELISA Kit can also be used to measure the pharmacokinetics of Ifabotuzumab, providing valuable information for dose optimization and treatment monitoring.

Advantages of Ifabotuzumab ELISA Kit

The Ifabotuzumab ELISA Kit offers several advantages over other methods for measuring Ifabotuzumab levels. This kit is highly sensitive, with a detection limit of 0.1 ng/mL, allowing for the accurate quantification of low levels of Ifabotuzumab in biological samples. It also has a wide dynamic range, from 0.156 to 10 ng/mL, making it suitable for both preclinical and clinical studies. In addition, the Ifabotuzumab ELISA Kit is easy to use, with a simple and straightforward protocol that can be completed within a few hours. This kit also has a high level of reproducibility, ensuring consistent and reliable results.

Conclusion

The Ifabotuzumab ELISA Kit is a valuable tool for researchers and clinicians working with Ifabotuzumab as a therapeutic agent for cancer. Its high sensitivity, specificity, and ease of use make it an ideal choice for monitoring Ifabotuzumab levels in various biological samples. This kit can also provide valuable information for optimizing treatment and evaluating the efficacy of Ifabotuzumab in different cancer models. With the increasing interest in Ifabotuzumab as a therapeutic target, the Ifabotuzumab ELISA Kit will continue to play a crucial role in supporting research and development in this field.