Onvatilimab Biosimilar – Anti-VSIR mAb – Research Grade

Description of Onvatilimab Biosimilar - Anti-VSIR mAb - Research Grade

Introduction

Onvatilimab Biosimilar, also known as Anti-VSIR mAb, is a research grade antibody that has been developed as a potential therapeutic for various diseases. This antibody specifically targets the VSIR protein, which plays a crucial role in regulating the immune response. In this article, we will discuss the structure, activity, and potential applications of Onvatilimab Biosimilar.

Structure of Onvatilimab Biosimilar

Onvatilimab Biosimilar is a monoclonal antibody, meaning it is derived from a single type of immune cell. It is produced through recombinant DNA technology, where the gene for the antibody is inserted into a host cell, such as Chinese hamster ovary (CHO) cells, to produce large quantities of the antibody. Onvatilimab Biosimilar has a molecular weight of approximately 150 kDa.

The antibody has a typical antibody structure, with two heavy chains and two light chains joined together by disulfide bonds. It also has a variable region that is responsible for binding to its target, VSIR. The constant region of the antibody is responsible for mediating its effector functions, such as activating the immune system to fight against the target.

Activity of Onvatilimab Biosimilar

The main activity of Onvatilimab Biosimilar is to bind to the VSIR protein and block its function. VSIR, also known as V-domain Ig suppressor of T cell activation, is a protein that is expressed on the surface of various immune cells, including T cells and B cells. It acts as a negative regulator of immune response, suppressing the activation and proliferation of these cells.

By binding to VSIR, Onvatilimab Biosimilar prevents it from interacting with its ligands, which are molecules that activate or inhibit its function. This leads to an increase in immune response, as the negative regulation by VSIR is inhibited. This activity of Onvatilimab Biosimilar makes it a potential therapeutic for diseases where the immune response needs to be enhanced, such as cancer and autoimmune disorders.

Potential Applications of Onvatilimab Biosimilar

Onvatilimab Biosimilar has shown promising results in preclinical studies for various diseases. It has been studied as a potential therapy for cancer, as VSIR has been found to be overexpressed in many types of cancer. By blocking VSIR, Onvatilimab Biosimilar can enhance the immune response against cancer cells and potentially lead to their destruction.

Furthermore, Onvatilimab Biosimilar has also been studied for its potential in treating autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. These diseases are characterized by an overactive immune response, which can be regulated by targeting VSIR with Onvatilimab Biosimilar.

In addition, Onvatilimab Biosimilar has shown potential in treating inflammatory diseases, such as asthma and allergic rhinitis. By enhancing the immune response, it can help to reduce inflammation and improve symptoms in these conditions.

Conclusion

Onvatilimab Biosimilar, also known as Anti-VSIR mAb, is a research grade antibody that specifically targets the VSIR protein. It has a typical antibody structure and its main activity is to block the negative regulation of immune response by VSIR. This makes it a potential therapeutic for various diseases, including cancer, autoimmune disorders, and inflammatory diseases. Further research and clinical trials are needed to fully understand the potential of Onvatilimab Biosimilar and its role in treating these diseases.