Recombinant Human CD56/NCAM1 Protein, N-His

Description of Recombinant Human CD56/NCAM1 Protein, N-His

Recombinant Human CD56/NCAM1 Protein: Structure, Activity, and Application

Introduction

Recombinant proteins are proteins that are produced through genetic engineering techniques, allowing for the production of large quantities of a specific protein. These proteins have various applications in fields such as medicine, biotechnology, and research. One such recombinant protein is the Recombinant Human CD56/NCAM1 Protein, which has gained significant attention in the scientific community due to its unique structure, diverse activity, and potential applications.

Structure of Recombinant Human CD56/NCAM1 Protein

The Recombinant Human CD56/NCAM1 Protein, also known as Neural Cell Adhesion Molecule 1 (NCAM1), is a glycoprotein that belongs to the immunoglobulin superfamily. It is composed of five immunoglobulin-like domains, a transmembrane region, and a cytoplasmic domain. The extracellular domains of CD56/NCAM1 contain several N-glycosylation sites, which are important for its function. The cytoplasmic domain of CD56/NCAM1 plays a crucial role in signal transduction and cell adhesion.

Activity of Recombinant Human CD56/NCAM1 Protein

CD56/NCAM1 is primarily expressed on the surface of neurons and plays a vital role in cell adhesion, migration, and differentiation. It is also found on other cell types, including natural killer cells, T cells, and glial cells. CD56/NCAM1 has been shown to be involved in various cellular processes, such as neurite outgrowth, synaptic plasticity, and immune response. It is also known to interact with other cell adhesion molecules, such as integrins and cadherins, to mediate cell-cell interactions.

Neuronal Function

In the nervous system, CD56/NCAM1 is involved in the formation and maintenance of synapses, which are crucial for proper neuronal communication. It also plays a role in neuronal plasticity, which is essential for learning and memory. Studies have shown that CD56/NCAM1 deficiency in mice leads to impaired learning and memory, highlighting its importance in neuronal function.

Immune Response

CD56/NCAM1 is also expressed on certain immune cells, where it acts as a co-stimulatory molecule and modulates immune responses. It has been shown to enhance the cytotoxic activity of natural killer cells and regulate T cell activation and proliferation. Additionally, CD56/NCAM1 has been implicated in the development and function of immune cells, making it a potential target for immunotherapy.

Application of Recombinant Human CD56/NCAM1 Protein

The unique structure and diverse activity of CD56/NCAM1 make it a valuable tool in various scientific applications. One of its primary uses is as a biomarker for diagnosing and monitoring certain diseases, including neurodevelopmental disorders and certain cancers. Additionally, recombinant CD56/NCAM1 protein has been used in research to study its role in neuronal development, synaptic plasticity, and immune response.

Diagnostic Tool

CD56/NCAM1 is highly expressed in certain cancers, such as small cell lung cancer and neuroblastoma. Therefore, it can be used as a biomarker for the diagnosis and monitoring of these cancers. Its expression has also been linked to disease progression and prognosis, making it a potential target for therapeutic interventions.

Research Tool

The use of recombinant CD56/NC