Recombinant Human EIF2AK1 Protein, N-His

Description of Recombinant Human EIF2AK1 Protein, N-His

Introduction to Recombinant Human EIF2AK1 Protein

Recombinant Human EIF2AK1 Protein, also known as eukaryotic translation initiation factor 2-alpha kinase 1, is a protein that plays a crucial role in regulating protein synthesis in human cells. It is a member of the serine/threonine protein kinase family and is encoded by the EIF2AK1 gene.

Structure of Recombinant Human EIF2AK1 Protein

Recombinant Human EIF2AK1 Protein is a 66 kDa protein composed of 528 amino acids. It consists of multiple domains, including a kinase domain, a regulatory domain, and a C-terminal domain. The kinase domain is responsible for the catalytic activity of the protein, while the regulatory domain helps in the regulation of its activity. The C-terminal domain is involved in protein-protein interactions.

The crystal structure of Recombinant Human EIF2AK1 Protein has been determined, revealing the presence of two lobes in the kinase domain. These lobes are connected by a hinge region and contain a conserved ATP-binding site and a substrate-binding site. The regulatory domain is located at the N-terminus and contains multiple phosphorylation sites that can modulate the activity of the protein.

Activity of Recombinant Human EIF2AK1 Protein

Recombinant Human EIF2AK1 Protein is a key regulator of the integrated stress response pathway. It is activated in response to various cellular stresses, such as nutrient deprivation, viral infection, and oxidative stress. Upon activation, it phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α), leading to the inhibition of protein synthesis.

In addition to its role in regulating protein synthesis, Recombinant Human EIF2AK1 Protein has also been implicated in other cellular processes. It has been shown to play a role in cell survival, autophagy, and the unfolded protein response. It can also regulate the expression of genes involved in cell proliferation and differentiation.

Application of Recombinant Human EIF2AK1 Protein

Recombinant Human EIF2AK1 Protein has various applications in both basic research and drug development. Its involvement in the integrated stress response pathway makes it a valuable tool for studying cellular stress responses. It can also be used to investigate the role of eIF2α phosphorylation in different cellular processes.

Furthermore, Recombinant Human EIF2AK1 Protein has potential therapeutic applications. As it is involved in regulating cell survival and proliferation, it has been studied as a target for cancer treatment. Inhibitors of Recombinant Human EIF2AK1 Protein have shown promising results in preclinical studies, making it a potential target for anticancer drugs.

In addition, Recombinant Human EIF2AK1 Protein has been linked to several neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. It has been shown to play a role in the formation of protein aggregates, a hallmark of these diseases. Therefore, it has been proposed as a potential therapeutic target for these conditions.

Conclusion

Recombinant Human EIF2AK1 Protein is a multifunctional protein that plays a crucial role in regulating protein synthesis and other cellular processes. Its structure consists of multiple domains that contribute to its activity and regulation. It has various applications in both basic research and drug development, making it a valuable protein for scientific study.

Overall, Recombinant Human EIF2AK1 Protein is a promising target for therapeutic interventions in various diseases, and further research on its structure and function may lead to the development of new treatments.