Recombinant Human FABP2, N-His

Description of Recombinant Human FABP2, N-His

Introduction

Recombinant Human FABP2, N-His is a protein that plays a crucial role in lipid metabolism and transport. It belongs to the fatty acid-binding protein (FABP) family, which consists of small cytosolic proteins that bind and transport fatty acids and other lipophilic substances. This protein has been extensively studied for its potential as a drug target due to its involvement in various metabolic disorders and diseases. In this article, we will discuss the structure, activity, and potential applications of Recombinant Human FABP2, N-His.

Structure of Recombinant Human FABP2, N-His

Recombinant Human FABP2, N-His is a 15 kDa protein that consists of 132 amino acids. It has a three-dimensional structure similar to other members of the FABP family, with a beta-barrel core surrounded by alpha-helices. The protein also has a binding pocket that can accommodate long-chain fatty acids and other lipophilic molecules.

The N-His tag in the protein’s name refers to a histidine tag that is added during the recombinant production process. This tag allows for easy purification and detection of the protein. It does not affect the structure or function of the protein, making it an ideal addition for research purposes.

Activity of this protein

Recombinant Human FABP2, N-His is primarily involved in the transport of fatty acids and other lipophilic substances in the body. It is highly expressed in the small intestine, where it plays a crucial role in the absorption and transport of dietary fatty acids. The protein binds to long-chain fatty acids and facilitates their transport across the intestinal epithelium into the bloodstream.

In addition to its role in lipid metabolism, Recombinant Human FABP2, N-His has also been found to be involved in the regulation of glucose metabolism. It has been shown to interact with insulin and modulate its activity, suggesting a potential role in glucose homeostasis.

Potential Applications of Recombinant Human FABP2, N-His

Due to its involvement in lipid and glucose metabolism, Recombinant Human FABP2, N-His has been studied as a potential drug target for various metabolic disorders and diseases. For instance, it has been suggested as a target for the treatment of type 2 diabetes, as its inhibition can improve insulin sensitivity and glucose uptake.

The protein has also been linked to atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. Recombinant Human FABP2, N-His has been proposed as a potential biomarker for atherosclerosis, as its levels have been found to be elevated in individuals with the condition.

Furthermore, studies have shown that Recombinant Human FABP2, N-His may play a role in the development of obesity and other metabolic disorders. Its inhibition has been shown to reduce body weight and improve lipid profiles in animal models, making it a potential target for the treatment of obesity.

Conclusion

In conclusion, Recombinant Human FABP2, N-His is a small cytosolic protein that plays a crucial role in lipid and glucose metabolism. Its structure, activity, and potential applications make it an attractive target for the treatment of various metabolic disorders and diseases. Further research on this protein may lead to the development of novel therapies for these conditions.