Recombinant Human FGF16 Protein, N-His-SUMO

Description of Recombinant Human FGF16 Protein, N-His-SUMO

Introduction

Recombinant Human FGF16 Protein is a type of recombinant protein that has been engineered through genetic manipulation to mimic the structure and function of the human fibroblast growth factor 16 (FGF16) protein. This protein plays a crucial role in various biological processes, making it a valuable tool in scientific research and potential therapeutic applications. In this article, we will explore the structure, activity, and potential applications of Recombinant Human FGF16 Protein.

Structure of Recombinant Human FGF16 Protein

Recombinant Human FGF16 Protein is a 21-kDa protein consisting of 192 amino acids. It shares a high degree of sequence similarity with other members of the FGF family, particularly with FGF2 and FGF9. The protein has a conserved core region, which is responsible for its biological activity, and a variable N-terminal region, which determines its specificity for different receptors.

The crystal structure of Recombinant Human FGF16 Protein has been determined, revealing a compact globular structure with 12 beta strands and 6 alpha helices. The protein also contains two disulfide bonds, which are essential for its stability and activity.

Activity of Recombinant Human FGF16 Protein

Recombinant Human FGF16 Protein is a potent mitogen, meaning it stimulates cell division and proliferation. It exerts its effects by binding to specific cell surface receptors, known as FGF receptors (FGFRs). These receptors are present on the surface of various cell types, including epithelial, endothelial, and mesenchymal cells.

Upon binding to FGFRs, Recombinant Human FGF16 Protein triggers a cascade of signaling events that ultimately lead to cell growth, survival, and differentiation. It also plays a role in angiogenesis, the process of forming new blood vessels, by stimulating the proliferation of endothelial cells.

In addition to its mitogenic activity, Recombinant Human FGF16 Protein has been shown to have neurotrophic and neuroprotective effects. It promotes the survival and differentiation of neurons, making it a potential therapeutic agent for neurodegenerative diseases.

Applications of Recombinant Human FGF16 Protein

Recombinant Human FGF16 Protein has a wide range of applications in scientific research and potential therapeutic use. Here are some of its most notable applications:

1. Cell Culture Studies

Recombinant Human FGF16 Protein is commonly used in cell culture studies to investigate its effects on cell growth, survival, and differentiation. It is also used to study the signaling pathways activated by FGF16 and its interactions with other growth factors and cytokines.

2. Tissue Engineering

Due to its mitogenic and angiogenic properties, Recombinant Human FGF16 Protein has been explored as a potential growth factor for tissue engineering applications. It has been shown to promote the proliferation and differentiation of various cell types, including stem cells, making it a promising candidate for tissue regeneration.

3. Wound Healing

Recombinant Human FGF16 Protein has been investigated for its potential in promoting wound healing. It has been shown to accelerate the healing process by stimulating the proliferation of epithelial cells and the formation of new blood vessels.

4. Neurodegenerative Diseases

As mentioned earlier, Recombinant Human FGF16 Protein has neurotrophic and neuroprotective effects, making it a potential therapeutic agent for neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It has been shown to promote neuronal survival and differentiation, and further research is being conducted to explore its potential in treating these diseases.

5. Cancer Research

Aberrant FGF signaling has been linked to various types of cancer, making Recombinant Human FGF16 Protein a valuable tool in cancer research. It has been used to investigate the role of FGF16 in cancer development and progression and to develop potential targeted therapies.

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