Recombinant Human GIPC1 Protein, N-His

Description of Recombinant Human GIPC1 Protein, N-His

Introduction

Recombinant Human GIPC1 Protein, also known as GAIP-interacting protein C-terminus 1, is a protein that plays a crucial role in various cellular processes. It is a 55 kDa protein that is encoded by the GIPC1 gene. This protein is highly conserved among different species, indicating its importance in biological functions. In this article, we will discuss the structure, activity, and applications of Recombinant Human GIPC1 Protein.

Structure of Recombinant Human GIPC1 Protein

Recombinant Human GIPC1 Protein is composed of 475 amino acids and has a molecular weight of 55 kDa. It contains several domains, including a PDZ domain, a TPR domain, and a C-terminal domain. The PDZ domain is responsible for protein-protein interactions, while the TPR domain is involved in protein binding and folding. The C-terminal domain is responsible for the binding of G protein-coupled receptors and other signaling molecules.

Activity of Recombinant Human GIPC1 Protein

Recombinant Human GIPC1 Protein is involved in various cellular processes, including cell signaling, cell adhesion, and endocytosis. It interacts with various proteins, such as G protein-coupled receptors, growth factor receptors, and ion channels, to regulate their activity. This protein also plays a crucial role in cell adhesion by regulating the formation and stability of cell-cell junctions. In addition, it is involved in endocytosis, the process by which cells internalize molecules from the extracellular environment.

One of the key activities of Recombinant Human GIPC1 Protein is its role in cell signaling. It acts as an adaptor protein, linking different signaling pathways to regulate cellular responses. For example, it interacts with the epidermal growth factor receptor (EGFR) to regulate cell proliferation and survival. It also interacts with the transforming growth factor-β (TGF-β) receptor to regulate cell growth and differentiation. Moreover, Recombinant Human GIPC1 Protein is involved in the regulation of the Wnt signaling pathway, which plays a crucial role in embryonic development and tissue homeostasis.

Applications of Recombinant Human GIPC1 Protein

Due to its diverse activities, Recombinant Human GIPC1 Protein has numerous applications in both basic research and clinical settings. One of the main applications of this protein is in the study of cell signaling pathways. Its interactions with various signaling molecules make it a valuable tool for understanding the complex network of cellular communication. In addition, Recombinant Human GIPC1 Protein is used in the development of new therapeutic strategies for diseases that involve dysregulation of cell signaling, such as cancer and neurodegenerative disorders.

Another important application of Recombinant Human GIPC1 Protein is in the field of drug discovery. As this protein is involved in the regulation of various signaling pathways, it can be targeted for the development of new drugs. For example, targeting the interaction between Recombinant Human GIPC1 Protein and EGFR has been shown to inhibit cell proliferation and induce cell death in cancer cells. This approach has the potential to be used in the treatment of various types of cancer.

In addition, Recombinant Human GIPC1 Protein has been used in the development of diagnostic tools for certain diseases. For example, it has been shown to be a potential biomarker for ovarian cancer, as its expression is significantly increased in ovarian cancer tissues compared to normal tissues. This makes it a promising candidate for the development of diagnostic tests for early detection of ovarian cancer.

Conclusion

In summary, Recombinant Human GIPC1 Protein is a highly conserved protein that plays a crucial role in various cellular processes. Its structure, activity, and applications make it a valuable tool for understanding cell signaling and developing new therapeutic strategies for diseases. Further research on this protein may lead to the development of new diagnostic tools and treatments for various diseases.