Recombinant Human HTR7 Protein, N-His-SUMO

Description of Recombinant Human HTR7 Protein, N-His-SUMO

Introduction to Recombinant Human HTR7 Protein

Recombinant Human HTR7 Protein is a protein that plays a crucial role in the central nervous system. This protein is encoded by the HTR7 gene and belongs to the G protein-coupled receptor family. It is also known as the serotonin receptor 7 or 5-hydroxytryptamine receptor 7.

Structure of Recombinant Human HTR7 Protein

Recombinant Human HTR7 Protein has a complex structure that consists of 7 transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. The N-terminus of the protein is responsible for binding to its ligand, serotonin. Upon binding, the protein undergoes a conformational change, which activates the intracellular signaling pathway.

The protein also has multiple phosphorylation sites, which can regulate its activity. These sites are important for the proper functioning of the protein and can be targeted by various drugs for therapeutic purposes.

Activity of Recombinant Human HTR7 Protein

Recombinant Human HTR7 Protein is a G protein-coupled receptor, which means it activates intracellular signaling pathways upon binding to its ligand. This protein specifically binds to serotonin, a neurotransmitter that is involved in regulating mood, behavior, and cognition.

Upon binding, the protein activates the G protein, which in turn activates the enzyme adenylyl cyclase. This enzyme is responsible for converting ATP into cyclic AMP (cAMP), a second messenger that plays a crucial role in cellular signaling. The increase in cAMP levels leads to the activation of downstream signaling pathways, which ultimately results in changes in neuronal activity.

The activity of Recombinant Human HTR7 Protein is not limited to the central nervous system. It has also been found to play a role in the gastrointestinal tract, cardiovascular system, and immune system. This highlights the diverse functions of this protein and its potential as a therapeutic target.

Application of Recombinant Human HTR7 Protein

Recombinant Human HTR7 Protein has been extensively studied for its potential therapeutic applications. One of the main areas of research is its role in psychiatric disorders, particularly depression and anxiety. Studies have shown that targeting this protein with specific drugs can modulate neuronal activity and improve symptoms of these disorders.

The protein has also been studied for its potential role in gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. It has been found to regulate gut motility and inflammation, making it a promising target for the development of new treatments.

In addition, Recombinant Human HTR7 Protein has been investigated for its potential role in cardiovascular diseases, such as hypertension and heart failure. It has been shown to regulate blood pressure and heart rate, making it a potential therapeutic target for these conditions.

Furthermore, the protein has been studied for its role in immune function and inflammation. It has been found to modulate the activity of immune cells, suggesting its potential use in treating inflammatory conditions.

Conclusion

In conclusion, Recombinant Human HTR7 Protein is a crucial protein that plays a role in various physiological processes. Its complex structure and activity make it an attractive target for therapeutic interventions in a wide range of diseases. Further research on this protein can potentially lead to the development of new treatments for psychiatric, gastrointestinal, cardiovascular, and inflammatory disorders.