Recombinant Human NDEL1 Protein, N-His

Description of Recombinant Human NDEL1 Protein, N-His

Introduction

Recombinant proteins have become essential tools in various fields of biotechnology, medicine and research due to their ability to mimic natural proteins and perform specific functions. One such protein is the Recombinant Human NDEL1 Protein, which has gained significant attention in recent years for its role in neurodevelopment and neurodegenerative diseases. In this article, we will discuss the structure, activity and application of this protein in detail.

Structure of Recombinant Human NDEL1 Protein

The Recombinant Human NDEL1 Protein is a member of the NudE family of proteins, which are involved in microtubule organization and neuronal migration during brain development. It is a 34 kDa protein composed of 306 amino acids, with a conserved N-terminal domain and a C-terminal domain that is unique to NDEL1. The N-terminal domain contains a coiled-coil region, which is responsible for protein-protein interactions, while the C-terminal domain contains a LisH motif that is involved in microtubule binding.

The crystal structure of Recombinant Human NDEL1 Protein has been determined, revealing a three-dimensional structure with a central helix surrounded by two beta sheets. This structure is similar to other NudE family proteins and is crucial for its function in microtubule regulation.

Activity of Recombinant Human NDEL1 Protein

Recombinant Human NDEL1 Protein plays a crucial role in neuronal migration and brain development. It interacts with other proteins, such as Lis1 and dynein, to regulate microtubule dynamics and promote proper neuronal migration. It also plays a role in the maintenance of neuronal polarity and axon formation.

Furthermore, studies have shown that Recombinant Human NDEL1 Protein is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. It has been found to interact with beta-amyloid and alpha-synuclein, two proteins that are associated with these diseases, and may contribute to their pathological processes.

Application of Recombinant Human NDEL1 Protein

The unique structure and activity of Recombinant Human NDEL1 Protein make it a valuable tool in various applications. One major application is in the study of neurodevelopment and neurodegenerative diseases. Recombinant Human NDEL1 Protein can be used to investigate the role of this protein in neuronal migration and brain development. It can also be used to study its interactions with other proteins and their implications in neurodegenerative diseases.

Moreover, Recombinant Human NDEL1 Protein has potential therapeutic applications. As it is involved in the pathogenesis of neurodegenerative diseases, targeting this protein could be a potential strategy for treating these diseases. Recombinant Human NDEL1 Protein can also be used for drug screening and development, as well as for the production of antibodies for diagnostic purposes.

Conclusion

In conclusion, Recombinant Human NDEL1 Protein is a crucial player in neurodevelopment and neurodegenerative diseases. Its unique structure and activity make it a valuable tool for research and potential therapeutic applications. With further studies and advancements in recombinant protein technology, the potential of Recombinant Human NDEL1 Protein in understanding and treating neurological disorders is immense.