Recombinant Human NDUFV2 Protein, N-His

Description of Recombinant Human NDUFV2 Protein, N-His

Introduction

The Recombinant Human NDUFV2 Protein is a highly purified and bioactive protein that is produced through recombinant DNA technology. This protein is a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which is essential for the conversion of NADH to NAD+ in the process of oxidative phosphorylation. The NDUFV2 protein is involved in the transfer of electrons from NADH to the respiratory chain, making it a crucial component in cellular energy production. In this article, we will discuss the structure, activity, and applications of this recombinant protein.

Structure of Recombinant Human NDUFV2 Protein

The Recombinant Human NDUFV2 Protein is a 24-kDa protein that consists of 205 amino acids. It is composed of two subunits, a larger alpha subunit and a smaller beta subunit. The alpha subunit contains the active site for NADH binding, while the beta subunit is responsible for the transfer of electrons to the respiratory chain. The structure of this protein is highly conserved among different species, indicating its importance in cellular function.

Activity of Recombinant Human NDUFV2 Protein

The main function of the Recombinant Human NDUFV2 Protein is to catalyze the transfer of electrons from NADH to the respiratory chain. This process is essential for the production of ATP, the energy currency of the cell. The NDUFV2 protein is part of the larger Complex I, which is the first and largest enzyme complex in the respiratory chain. It is responsible for the transfer of electrons from NADH to ubiquinone, a crucial step in the production of ATP.

In addition to its role in energy production, the NDUFV2 protein also plays a part in regulating cellular metabolism. It has been shown to interact with other proteins involved in metabolic pathways, such as the TCA cycle and fatty acid metabolism. This suggests that the NDUFV2 protein has a broader role in cellular function beyond its primary function in the respiratory chain.

Applications of Recombinant Human NDUFV2 Protein

The Recombinant Human NDUFV2 Protein has a wide range of applications in both research and clinical settings. Due to its crucial role in cellular energy production, this protein is often used in studies related to mitochondrial function and metabolism. It is also used in drug discovery and development, as defects in Complex I have been linked to various diseases, including Parkinson’s disease and Alzheimer’s disease.

Furthermore, the NDUFV2 protein has potential as a diagnostic and therapeutic target. Mutations in the gene encoding this protein have been associated with mitochondrial disorders, making it a potential biomarker for these conditions. Additionally, drugs that target Complex I, such as rotenone and metformin, have been shown to interact with the NDUFV2 protein, further highlighting its potential as a therapeutic target.

Conclusion

The Recombinant Human NDUFV2 Protein is a vital component of the mitochondrial respiratory chain, playing a crucial role in energy production and cellular metabolism. Its highly conserved structure and diverse functions make it an essential protein in both research and clinical applications. As our understanding of the NDUFV2 protein continues to grow, it is likely that its potential as a diagnostic and therapeutic target will also increase, making it an exciting protein to study in the field of biochemistry and molecular biology.