Recombinant Human NECTIN4/PVRL4 Protein, N-His

Description of Recombinant Human NECTIN4/PVRL4 Protein, N-His

Introduction

Recombinant Human NECTIN4/PVRL4 Protein is a highly versatile protein that plays a crucial role in various biological processes. It belongs to the immunoglobulin superfamily and is encoded by the PVRL4 gene. This protein is also known as Nectin-4 or poliovirus receptor-related protein 4 and is involved in cell adhesion, proliferation, and signaling. In this article, we will discuss the structure, activity, and applications of Recombinant Human NECTIN4/PVRL4 Protein.

Structure of Recombinant Human NECTIN4/PVRL4 Protein

Recombinant Human NECTIN4/PVRL4 Protein is a type I transmembrane protein with a molecular weight of approximately 65 kDa. It is composed of a single extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain consists of three immunoglobulin-like domains (V, C1, and C2) that are responsible for mediating cell adhesion and binding to other proteins. The transmembrane domain anchors the protein to the cell membrane, while the cytoplasmic domain interacts with intracellular signaling molecules.

Activity of Recombinant Human NECTIN4/PVRL4 Protein

Recombinant Human NECTIN4/PVRL4 Protein is primarily involved in cell adhesion and signaling. It is expressed in various tissues, including epithelial cells, endothelial cells, and immune cells. This protein forms homophilic and heterophilic interactions with other NECTIN family members, such as NECTIN1, NECTIN2, and NECTIN3, to regulate cell-cell adhesion and maintain tissue integrity. It also interacts with other proteins, such as integrins and cadherins, to mediate cell adhesion and migration.

Apart from its role in cell adhesion, Recombinant Human NECTIN4/PVRL4 Protein also plays a crucial role in cell signaling. It can activate various signaling pathways, such as the PI3K/Akt and MAPK/ERK pathways, to regulate cell growth, survival, and proliferation. Furthermore, this protein has been shown to modulate immune responses by interacting with immune cells and regulating their activation and function.

Applications of Recombinant Human NECTIN4/PVRL4 Protein

Recombinant Human NECTIN4/PVRL4 Protein has numerous applications in both research and clinical settings. Due to its role in cell adhesion and signaling, it has been extensively studied in cancer research. NECTIN4 is overexpressed in various types of cancer, including breast, lung, and bladder cancer, making it a potential therapeutic target. Recombinant Human NECTIN4/PVRL4 Protein has been used in preclinical studies to inhibit cancer cell growth and migration, and it is currently being evaluated in clinical trials for the treatment of cancer.

Moreover, Recombinant Human NECTIN4/PVRL4 Protein has also been studied in infectious diseases. It is a receptor for poliovirus and herpes simplex virus, and its expression has been linked to the severity of viral infections. Recombinant Human NECTIN4/PVRL4 Protein has been used in studies to understand the mechanism of viral entry and to develop antiviral therapies.

In addition to cancer and infectious diseases, Recombinant Human NECTIN4/PVRL4 Protein has potential applications in regenerative medicine. It has been shown to promote the differentiation of stem cells into epithelial cells and is being investigated for its role in tissue repair and regeneration.

Conclusion

In conclusion, Recombinant Human NECTIN4/PVRL4 Protein is a versatile protein with a crucial role in cell adhesion, signaling, and immune responses. Its structure, activity, and applications make it a valuable tool in various fields of research, including cancer, infectious diseases, and regenerative medicine. Further studies on this protein may lead to the development of