Recombinant Human NTF3, N-His

Description of Recombinant Human NTF3, N-His

Introduction

Recombinant Human NTF3, N-His is a protein that has been genetically engineered in the laboratory to mimic the natural human protein Nerve Growth Factor (NGF). It belongs to the family of neurotrophins, which are essential for the development and maintenance of the nervous system. NTF3, N-His is a promising drug target for various neurological disorders due to its ability to promote nerve cell growth and survival. In this article, we will discuss the structure, activity, and potential applications of this protein.

Structure of Recombinant Human NTF3, N-His

Recombinant Human NTF3, N-His is a 119 amino acid protein with a molecular weight of approximately 13 kDa. It is composed of two identical subunits, each containing a cysteine-knot structure and a β-sheet-rich core. The cysteine-knot structure is crucial for the stability and function of the protein. The N-His tag, a sequence of six histidine residues, is attached to the N-terminus of the protein. This tag allows for easy purification and detection of the protein.

Activity of this protein

NTF3, N-His is a potent neurotrophic factor that plays a crucial role in the survival, differentiation, and maintenance of various types of nerve cells. It binds to its specific receptor, TrkC, and activates several signaling pathways, including the PI3K-Akt and MAPK pathways. These pathways are involved in cell growth, survival, and differentiation. NTF3, N-His also promotes the formation of new synapses, which are essential for proper brain function.

Applications of Recombinant Human NTF3, N-His

1. Treatment of Neurological Disorders

Recombinant Human NTF3, N-His has shown promising results in preclinical studies for the treatment of various neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and spinal cord injury. It has been shown to promote nerve cell growth and survival, which can potentially slow down the progression of these diseases.

2. Nerve Regeneration

NTF3, N-His has the ability to stimulate the regeneration of damaged nerves. This makes it a potential therapeutic option for conditions that involve nerve damage, such as peripheral neuropathy and diabetic neuropathy.

3. Wound Healing

The neurotrophic activity of NTF3, N-His has also been explored in the field of wound healing. It has been shown to promote the growth and migration of skin cells, which can accelerate the healing process of wounds.

4. Gene Therapy

Recombinant Human NTF3, N-His can be used in gene therapy to deliver the NTF3 gene to specific cells. This approach has shown promising results in the treatment of neurodegenerative diseases, where the delivery of neurotrophic factors directly to the affected cells is crucial.

5. Research Tool

NTF3, N-His is widely used as a research tool to study the mechanisms of nerve cell growth and development. Its ability to promote the survival and differentiation of nerve cells makes it a valuable tool for studying various neurological disorders.

Conclusion

Recombinant Human NTF3, N-His is a promising drug target for various neurological disorders due to its potent neurotrophic activity. Its structure, activity, and potential applications make it a valuable protein in the field of neuroscience. Further research and clinical trials are needed to fully understand the therapeutic potential of this protein and its role in the treatment of neurological disorders.