Recombinant Human PLAGL2 Protein, N-His

Description of Recombinant Human PLAGL2 Protein, N-His

Introduction to Recombinant Human PLAGL2 Protein

Recombinant Human PLAGL2 Protein, also known as pleomorphic adenoma gene-like 2 protein, is a member of the PLAG family of zinc finger transcription factors. It is encoded by the PLAGL2 gene located on chromosome 20q11.2. PLAGL2 plays a crucial role in regulating cellular processes such as proliferation, differentiation, and apoptosis. It is highly expressed in various tissues and has been found to be dysregulated in several types of cancer, making it an important target for research and therapeutic development.

Structure of Recombinant Human PLAGL2 Protein

Recombinant Human PLAGL2 Protein is a 72 kDa protein consisting of 621 amino acids. It contains six C2H2-type zinc fingers, which are responsible for DNA binding and transcriptional regulation. These zinc fingers are arranged in a modular fashion, with three fingers in the N-terminal region and three in the C-terminal region. This unique structure allows PLAGL2 to bind to specific DNA sequences and regulate gene expression.

Activity of Recombinant Human PLAGL2 Protein

Recombinant Human PLAGL2 Protein has been shown to have both transcriptional activation and repression activity. It acts as a transcription factor by binding to specific DNA sequences and regulating the expression of target genes. PLAGL2 has been found to regulate the expression of genes involved in cell cycle progression, apoptosis, and differentiation. It also interacts with other proteins to form transcriptional complexes, further modulating its activity.

Recent studies have also shown that PLAGL2 has non-transcriptional functions, such as promoting cell migration and invasion. This activity is mediated by the interaction of PLAGL2 with other proteins involved in cytoskeletal organization and cell adhesion. These non-transcriptional functions of PLAGL2 have been implicated in cancer progression and metastasis.

Application of Recombinant Human PLAGL2 Protein

Recombinant Human PLAGL2 Protein has been widely used in research to study its role in various cellular processes and diseases. It is also being explored as a potential therapeutic target for cancer treatment. Recombinant PLAGL2 protein can be produced in large quantities using recombinant DNA technology, making it easily accessible for research purposes.

One of the major applications of Recombinant Human PLAGL2 Protein is in cancer research. PLAGL2 has been found to be overexpressed in several types of cancer, including breast, lung, and colon cancer. It has been shown to promote tumor growth and metastasis by regulating the expression of genes involved in these processes. Targeting PLAGL2 with specific inhibitors or by silencing its expression has shown promising results in inhibiting cancer growth and metastasis in preclinical studies.

In addition to cancer research, Recombinant Human PLAGL2 Protein has also been studied in other diseases such as diabetes and neurodegenerative disorders. PLAGL2 has been found to play a role in regulating insulin secretion and glucose metabolism, making it a potential target for diabetes treatment. It has also been linked to the development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s, and further research is being conducted to understand its role in these conditions.

In conclusion, Recombinant Human PLAGL2 Protein is a crucial protein involved in regulating various cellular processes and has been implicated in several diseases. Its unique structure and activity make it an important target for research and therapeutic development. Further studies on PLAGL2 are needed to fully understand its function and potential applications in various diseases.