Recombinant Human PTPRQ Protein, N-His

Description of Recombinant Human PTPRQ Protein, N-His

Introduction

Recombinant Human PTPRQ Protein is a protein that is produced through genetic engineering techniques, where specific DNA sequences are inserted into host cells to produce a desired protein. PTPRQ stands for Protein Tyrosine Phosphatase, Receptor Type Q, and it is a member of the protein tyrosine phosphatase (PTP) family. This protein plays a crucial role in various cellular processes and has been extensively studied for its structure, activity, and potential applications.

Structure of Recombinant Human PTPRQ Protein

Recombinant Human PTPRQ Protein is composed of 1111 amino acids and has a molecular weight of approximately 125 kDa. It consists of a single transmembrane domain, a cytoplasmic domain, and an extracellular domain. The extracellular domain contains multiple fibronectin type III repeats, which are involved in protein-protein interactions. The cytoplasmic domain contains two catalytic domains, D1 and D2, which are responsible for the phosphatase activity of the protein.

Activity of Recombinant Human PTPRQ Protein

The main function of Recombinant Human PTPRQ Protein is to dephosphorylate tyrosine residues on target proteins. This activity is crucial for regulating various cellular processes, such as cell growth, differentiation, and signaling. PTPRQ has been shown to interact with multiple proteins, including growth factor receptors, ion channels, and cytoskeletal proteins, through its extracellular and cytoplasmic domains. By dephosphorylating these proteins, PTPRQ can modulate their activity and affect downstream signaling pathways.

In addition to its phosphatase activity, Recombinant Human PTPRQ Protein has also been found to have adhesive properties. The fibronectin type III repeats in the extracellular domain play a role in cell-cell and cell-matrix interactions. This adhesive function may contribute to the protein’s role in cell adhesion and migration, which are essential processes in tissue development and repair.

Applications of Recombinant Human PTPRQ Protein

Given its diverse functions and interactions, Recombinant Human PTPRQ Protein has potential applications in various fields, including cancer research, neurobiology, and regenerative medicine.

One of the key roles of PTPRQ is to regulate cell growth and differentiation. Dysregulation of this protein has been linked to various types of cancers, making it a potential target for cancer therapy. Recombinant Human PTPRQ Protein can be used to study the mechanisms of PTPRQ in cancer development and as a potential therapeutic agent to inhibit its activity in cancer cells.

In the field of neurobiology, PTPRQ has been found to be highly expressed in the brain and is involved in neuronal development and function. Recombinant Human PTPRQ Protein can be used to study the role of this protein in neurological disorders and as a potential treatment for neurodegenerative diseases.

Furthermore, the adhesive properties of PTPRQ make it a potential candidate for tissue engineering and regenerative medicine. Recombinant Human PTPRQ Protein can be used to promote cell adhesion and migration in tissue scaffolds, aiding in tissue repair and regeneration.

Conclusion

Recombinant Human PTPRQ Protein is a multifunctional protein with diverse roles in cellular processes. Its structure, activity, and potential applications make it a promising target for research and therapeutic interventions in various fields. As our understanding of this protein continues to grow, it may hold even more potential for future discoveries and advancements in the scientific community.