Recombinant Human RNASE11, N-His

Description of Recombinant Human RNASE11, N-His

Introduction to Recombinant Human RNASE11

Recombinant Human RNASE11 is a type of recombinant protein that has been genetically engineered to mimic the activity of the human RNASE11 enzyme. This enzyme plays a crucial role in the breakdown of RNA molecules and has been found to have potential therapeutic applications in various diseases. In this article, we will explore the structure, activity, and applications of Recombinant Human RNASE11.

Structure of Recombinant Human RNASE11

Recombinant Human RNASE11 is a protein that consists of 134 amino acids and has a molecular weight of approximately 15 kDa. It is composed of a single polypeptide chain with a unique three-dimensional structure. The primary structure of this protein is determined by its DNA sequence, which is obtained through genetic engineering techniques.

The secondary structure of Recombinant Human RNASE11 is mainly composed of alpha-helices and beta-sheets, which are stabilized by hydrogen bonds. The tertiary structure of this protein is crucial for its biological activity and is formed by the folding of the secondary structure into a compact globular shape.

The active site of Recombinant Human RNASE11 is located in a cleft between two domains of the protein. This active site is responsible for the catalytic activity of the enzyme, which involves the cleavage of phosphodiester bonds in RNA molecules.

Activity of Recombinant Human RNASE11

The primary function of Recombinant Human RNASE11 is to degrade RNA molecules, which are essential for various cellular processes. This enzyme specifically targets single-stranded RNA molecules and cleaves them at specific locations, resulting in the formation of smaller fragments.

The activity of Recombinant Human RNASE11 is regulated by various factors, such as pH, temperature, and the presence of other molecules. It has been found that this enzyme has optimal activity at a slightly acidic pH and a temperature of around 37°C.

The catalytic activity of Recombinant Human RNASE11 is crucial for its potential therapeutic applications. It has been shown to have antiviral, antibacterial, and antitumor properties, making it a promising candidate for the treatment of various diseases.

Applications of Recombinant Human RNASE11

Recombinant Human RNASE11 has shown potential in various therapeutic applications due to its ability to degrade RNA molecules. One of its most promising applications is in the treatment of viral infections. It has been found to have significant antiviral activity against various RNA viruses, including influenza and HIV.

Another potential application of Recombinant Human RNASE11 is in the treatment of bacterial infections. This enzyme has been shown to have antibacterial activity against both Gram-positive and Gram-negative bacteria. It achieves this by degrading the RNA molecules essential for bacterial growth and survival.

Furthermore, Recombinant Human RNASE11 has also shown promise in the treatment of cancer. It has been found to have antitumor activity by inducing cell death in cancer cells through the degradation of their RNA molecules. This makes it a potential candidate for cancer therapy in the future.

Conclusion

In conclusion, Recombinant Human RNASE11 is a genetically engineered protein that mimics the activity of the human RNASE11 enzyme. It has a unique structure and plays a crucial role in the degradation of RNA molecules. Its potential therapeutic applications in antiviral, antibacterial, and antitumor treatments make it a promising candidate for further research and development.

Overall, the study of Recombinant Human RNASE11 has provided valuable insights into the structure and function of this enzyme, which can aid in the development of new treatments for various diseases. With ongoing research and advancements in genetic engineering techniques, the potential of this protein in the field of medicine is vast.