Recombinant Human S100A11, N-His

Description of Recombinant Human S100A11, N-His

Introduction to Recombinant Human S100A11, N-His

Recombinant Human S100A11, N-His is a protein that plays a crucial role in a variety of cellular processes. It is a member of the S100 family of calcium-binding proteins and is encoded by the S100A11 gene. This protein is highly conserved across species, with the human and mouse versions sharing 94% sequence identity. Recombinant Human S100A11, N-His is produced through genetic engineering techniques, making it a valuable tool for research and potential therapeutic applications.

Structure of Recombinant Human S100A11, N-His

The structure of Recombinant Human S100A11, N-His is composed of two identical polypeptide chains, each containing 91 amino acids. These chains are held together by disulfide bonds and are arranged in a compact globular shape. The protein contains two calcium-binding sites, which are essential for its function. The N-His tag, which is added during the production process, allows for easy purification and detection of the protein.

Function and Activity of this protein

Recombinant Human S100A11, N-His is a multifunctional protein that is involved in various cellular processes, including cell growth, differentiation, and apoptosis. It exerts its effects through interactions with other proteins, such as annexin A2, which is involved in cell signaling and membrane trafficking. The calcium-binding sites in Recombinant Human S100A11, N-His are crucial for these interactions, as they allow for conformational changes that facilitate binding to target proteins.

Studies have also shown that Recombinant Human S100A11, N-His plays a role in cancer development and progression. It has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer. This overexpression has been linked to increased cell proliferation and invasion, suggesting that Recombinant Human S100A11, N-His may be a potential drug target for cancer treatment.

Application of Recombinant Human S100A11, N-His

Recombinant Human S100A11, N-His has a wide range of applications in both research and potential therapeutic settings. Its ability to interact with other proteins and its involvement in various cellular processes make it a valuable tool for studying cell signaling and protein-protein interactions. The N-His tag also allows for easy detection and purification of the protein, making it a useful tool for protein purification and analysis.

In terms of therapeutic applications, Recombinant Human S100A11, N-His has shown potential as a drug target for cancer treatment. By targeting the protein and disrupting its interactions with other proteins, it may be possible to inhibit cancer cell growth and invasion. Additionally, the N-His tag on the protein could potentially be used in targeted drug delivery, allowing for more precise and efficient treatment of cancer cells.

Conclusion

Recombinant Human S100A11, N-His is a highly conserved protein with important functions in various cellular processes. Its structure, function, and potential as a drug target make it a valuable tool for research and potential therapeutic applications. As research on this protein continues, it may reveal even more potential uses and benefits, making it an exciting area of study in the field of molecular biology.