Recombinant Mouse BTN2A2 Protein, N-His

Description of Recombinant Mouse BTN2A2 Protein, N-His

Introduction

Recombinant Mouse BTN2A2 Protein is a highly versatile protein that has gained popularity in the scientific community due to its unique structure, diverse activity, and wide range of applications. This protein is a member of the B7 family of immune regulatory proteins and is encoded by the BTN2A2 gene in mice. It is also known as BTF3P11 or BT3.2.

Structure of Recombinant Mouse BTN2A2 Protein

Recombinant Mouse BTN2A2 Protein is a type I transmembrane protein that consists of 254 amino acids. It has a molecular weight of approximately 28 kDa and is composed of a single extracellular domain, a transmembrane domain, and a short cytoplasmic tail. The extracellular domain contains two immunoglobulin-like domains, IgV and IgC, which are responsible for protein-protein interactions. The transmembrane domain anchors the protein to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling.

Activity of Recombinant Mouse BTN2A2 Protein

Recombinant Mouse BTN2A2 Protein is a potent immune regulator that plays a crucial role in both innate and adaptive immunity. It is mainly expressed on the surface of antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. The protein interacts with its ligand, the butyrophilin-like 2 (BTNL2), on T cells, leading to the activation or suppression of T cell responses.

One of the key functions of Recombinant Mouse BTN2A2 Protein is its ability to modulate T cell activation and proliferation. Studies have shown that the protein can either enhance or inhibit T cell activation, depending on the context of the immune response. It has been reported that Recombinant Mouse BTN2A2 Protein can promote the differentiation of regulatory T cells, which are responsible for maintaining immune tolerance. This makes the protein a potential therapeutic target for autoimmune diseases and transplantation.

Moreover, Recombinant Mouse BTN2A2 Protein has been found to play a crucial role in the regulation of immune checkpoints. It can act as a co-stimulatory molecule, enhancing the activation of T cells, or as a co-inhibitory molecule, dampening T cell responses. This dual function of the protein makes it an attractive target for cancer immunotherapy.

Application of Recombinant Mouse BTN2A2 Protein

Recombinant Mouse BTN2A2 Protein has a wide range of applications in both basic and clinical research. Due to its role in immune regulation, it has been extensively studied in the context of various diseases, including cancer, autoimmune disorders, and infectious diseases.

In cancer research, Recombinant Mouse BTN2A2 Protein has been shown to have a potential role in tumor immunity. It has been reported that the protein is upregulated in various types of cancer, and its expression is associated with better clinical outcomes. This has led to the development of BTNL2-targeted therapies for cancer treatment.

In autoimmune diseases, Recombinant Mouse BTN2A2 Protein has been studied as a potential therapeutic target. It has been found to play a critical role in the development of autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. Targeting the protein with specific antibodies or small molecule inhibitors has shown promising results in preclinical studies.

Furthermore, Recombinant Mouse BTN2A2 Protein has been investigated in the context of infectious diseases. It has been reported that the protein is involved in the host immune response to viral and bacterial infections. Targeting Recombinant Mouse BTN2A2 Protein could potentially enhance the immune response and aid in the clearance of pathogens.

Conclusion

In conclusion, Recombinant Mouse BTN2A2 Protein is a multifunctional protein that plays a crucial role in immune regulation. Its unique structure and diverse activity make it a valuable tool for understanding the immune system and developing novel therapies for various diseases. With ongoing research and advancements