Recombinant Mouse BTNL2/BTL-II Protein, N-His

Description of Recombinant Mouse BTNL2/BTL-II Protein, N-His

Introduction to Recombinant Mouse BTNL2/BTL-II Protein

Recombinant Mouse BTNL2/BTL-II Protein is a type of recombinant protein that has been produced through genetic engineering techniques. It is a member of the B7 family of proteins, which are known for their role in regulating immune responses. The BTNL2 gene encodes for a transmembrane protein that is expressed on the surface of various immune cells, including T cells, B cells, and dendritic cells.

Structure of Recombinant Mouse BTNL2/BTL-II Protein

The recombinant form of BTNL2/BTL-II protein is a homodimer, meaning it is composed of two identical subunits. Each subunit consists of an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain is the part of the protein that interacts with other molecules, while the transmembrane domain anchors the protein to the cell membrane. The cytoplasmic domain is responsible for transmitting signals into the cell.

The extracellular domain of BTNL2/BTL-II protein contains a unique structure known as a B30.2 domain. This domain is found in other proteins involved in immune regulation and is thought to play a role in protein-protein interactions. The B30.2 domain of BTNL2/BTL-II protein is also responsible for its binding to its receptor, which is still under investigation.

Activity of Recombinant Mouse BTNL2/BTL-II Protein

The activity of BTNL2/BTL-II protein is primarily related to its role in regulating immune responses. Studies have shown that this protein can act as both a co-stimulatory and co-inhibitory molecule, depending on the context of the immune response. When bound to its receptor, BTNL2/BTL-II protein can enhance T cell activation and proliferation, leading to a stronger immune response. On the other hand, it can also inhibit T cell activation and promote immune tolerance, preventing an excessive or harmful immune response.

Additionally, BTNL2/BTL-II protein has been shown to play a role in the development and function of regulatory T cells, which are important for maintaining immune homeostasis and preventing autoimmune diseases. It has also been implicated in the regulation of cytokine production and the activation of other immune cells, such as natural killer cells and dendritic cells.

Application of Recombinant Mouse BTNL2/BTL-II Protein

Recombinant Mouse BTNL2/BTL-II Protein has a wide range of potential applications in the field of immunology. Its ability to modulate immune responses makes it a promising candidate for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. It may also have potential as a therapeutic target for cancer, as it has been shown to play a role in tumor immunity.

Furthermore, BTNL2/BTL-II protein has been investigated as a potential biomarker for certain diseases. For example, its expression has been found to be altered in patients with inflammatory bowel disease, making it a potential diagnostic tool for this condition.

In addition to its potential therapeutic and diagnostic applications, recombinant BTNL2/BTL-II protein is also commonly used as an antigen in research studies. Its unique structure and role in immune regulation make it a valuable tool for studying the mechanisms of immune responses and developing new treatments for immune-related disorders.

Conclusion

In summary, Recombinant Mouse BTNL2/BTL-II Protein is a homodimeric protein that plays a critical role in regulating immune responses. Its structure, activity, and potential applications make it a valuable tool for both basic research and clinical applications. Further studies on this protein may lead to the development of new treatments for various immune-related disorders.