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AntibodySystem
Recombinant Proteins
Recombinant Mouse CD267/TNFRSF13B Protein, also known as B cell maturation antigen (BCMA), is a transmembrane protein that plays a crucial role in the development and survival of B cells. It is a member of the tumor necrosis factor receptor superfamily and is primarily expressed on mature B cells, plasma cells, and a subset of T cells. In this article, we will explore the structure, activity, and application of this important protein.
The recombinant form of mouse CD267/TNFRSF13B protein is a 184 amino acid polypeptide with a molecular weight of approximately 21 kDa. It contains a single extracellular cysteine-rich domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain is responsible for binding to its ligands, while the cytoplasmic tail is involved in signal transduction.
Recombinant Mouse CD267/TNFRSF13B Protein plays a critical role in B cell development and survival. It functions as a receptor for two ligands, B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL). Binding of these ligands to CD267/TNFRSF13B results in the activation of downstream signaling pathways, including the NF-κB and MAPK pathways, which promote B cell survival and proliferation.
In addition to its role in B cell development, CD267/TNFRSF13B has also been implicated in the pathogenesis of autoimmune diseases and B cell malignancies. Studies have shown that dysregulation of CD267/TNFRSF13B signaling can lead to the development of autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. It has also been found to be highly expressed in multiple myeloma, a type of B cell cancer, making it a potential therapeutic target for this disease.
The recombinant form of mouse CD267/TNFRSF13B protein has a wide range of applications in both basic research and clinical settings. One of its most common uses is in the study of B cell biology. Recombinant CD267/TNFRSF13B protein can be used to investigate the role of this receptor in B cell development, survival, and function. It can also be used to study the effects of its ligands, BAFF and APRIL, on B cell signaling and function.
In addition to its use in basic research, recombinant CD267/TNFRSF13B protein has potential clinical applications. Due to its involvement in autoimmune diseases and B cell malignancies, it has been explored as a potential therapeutic target. Several studies have shown promising results in using CD267/TNFRSF13B inhibitors to treat autoimmune diseases and B cell cancers. Recombinant CD267/TNFRSF13B protein can also be used in the development of diagnostic assays for these diseases.
In summary, Recombinant Mouse CD267/TNFRSF13B Protein is a crucial player in B cell biology, with important roles in development, survival, and function. Its dysregulation has been linked to autoimmune diseases and B cell malignancies, making it a potential therapeutic target for these diseases. The recombinant form of this protein has a wide range of applications in both basic research and clinical settings, making it a valuable tool for studying B cell biology and developing potential treatments for related diseases.
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