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AntibodySystem
Recombinant Proteins
Recombinant Mouse CD317/BST2 Protein, also known as Bone Marrow Stromal Cell Antigen 2 (BST2) or Tetherin, is a type II transmembrane protein that plays a crucial role in the immune response against viral infections. This protein is encoded by the BST2 gene and is highly conserved among mammals. In this article, we will explore the structure, activity, and applications of this recombinant protein.
The recombinant Mouse CD317/BST2 protein is composed of 180 amino acids with a molecular weight of approximately 21 kDa. It consists of an N-terminal cytoplasmic domain, a transmembrane domain, and a C-terminal extracellular domain. The extracellular domain contains two N-linked glycosylation sites, which are important for protein stability and function.
Recombinant Mouse CD317/BST2 protein is a type II interferon-inducible protein that is expressed on the surface of various cell types, including immune cells such as T cells, B cells, and dendritic cells. This protein acts as a host restriction factor against enveloped viruses by preventing the release of newly formed viral particles from infected cells.
The activity of recombinant Mouse CD317/BST2 protein is mainly mediated through its interaction with viral proteins and host cell proteins. The extracellular domain of this protein contains a conserved region called the transmembrane domain-like (TMDL) region, which is responsible for its antiviral activity. The TMDL region interacts with the viral envelope glycoprotein, preventing its incorporation into the viral membrane and thereby inhibiting viral release.
In addition to its antiviral activity, recombinant Mouse CD317/BST2 protein also plays a role in immune cell activation and regulation. It has been shown to enhance the production of pro-inflammatory cytokines and chemokines, as well as promote the maturation and activation of dendritic cells.
The unique structure and activity of recombinant Mouse CD317/BST2 protein make it a valuable tool for various applications in research and biotechnology. Here are some of its key applications:
Recombinant Mouse CD317/BST2 protein has been extensively studied for its antiviral properties, particularly against enveloped viruses such as HIV, Ebola, and influenza. Its ability to inhibit viral release makes it a potential target for the development of antiviral therapies.
The expression of recombinant Mouse CD317/BST2 protein has been found to be dysregulated in various types of cancer, including breast cancer, lung cancer, and melanoma. This protein has been shown to play a role in tumor growth and metastasis, making it a potential target for cancer therapy.
The immune-regulatory properties of recombinant Mouse CD317/BST2 protein make it a promising candidate for immunotherapy. It has been shown to enhance the immune response against tumors and viral infections, making it a potential adjuvant for vaccines and cancer immunotherapy.
Recombinant Mouse CD317/BST2 protein can also be used as a diagnostic tool for viral infections. Its expression is upregulated in response to viral infections, making it a potential biomarker for the detection of viral diseases.
In conclusion, recombinant Mouse CD317/BST2 protein is a multifunctional protein with a unique structure and activity. Its antiviral and immune-regulatory properties make it a valuable tool for various applications in research and biotechnology. Further studies on this protein may lead to the development of novel antiviral therapies and immunotherapies for the treatment of various diseases.
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