Recombinant Mouse FGFR2 Protein, N-His

Description of Recombinant Mouse FGFR2 Protein, N-His

Introduction

Recombinant Mouse FGFR2 Protein, also known as Fibroblast Growth Factor Receptor 2, is a crucial protein involved in cell signaling and regulation. It is a transmembrane receptor that plays a vital role in various biological processes such as cell proliferation, differentiation, and migration. In this article, we will discuss the structure, activity, and applications of Recombinant Mouse FGFR2 Protein.

Structure of Recombinant Mouse FGFR2 Protein

Recombinant Mouse FGFR2 Protein is a type I transmembrane protein that belongs to the fibroblast growth factor receptor family. It is composed of three main domains: an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. The extracellular domain contains three immunoglobulin-like domains (D1-D3) that are responsible for binding to fibroblast growth factors (FGFs). The transmembrane domain anchors the protein to the cell membrane, while the intracellular domain contains the tyrosine kinase activity responsible for signal transduction.

Activity of Recombinant Mouse FGFR2 Protein

Recombinant Mouse FGFR2 Protein is activated by binding to specific FGF ligands, which leads to dimerization and autophosphorylation of the intracellular domain. This results in the activation of downstream signaling pathways, including the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play a crucial role in cell growth, differentiation, and survival.

The activity of Recombinant Mouse FGFR2 Protein is tightly regulated by various mechanisms, including ligand availability, receptor expression, and post-translational modifications. Dysregulation of FGFR2 signaling has been linked to various diseases, including cancer, skeletal disorders, and developmental abnormalities.

Applications of Recombinant Mouse FGFR2 Protein

Recombinant Mouse FGFR2 Protein has a wide range of applications in both research and therapeutic settings. Its role in cell signaling and regulation makes it a valuable tool for studying various cellular processes. Some of the notable applications of Recombinant Mouse FGFR2 Protein include:

1. Cancer Research

Aberrant FGFR2 signaling has been implicated in the development and progression of various cancers, including breast, lung, and gastric cancer. Recombinant Mouse FGFR2 Protein is used in cancer research to study the mechanisms underlying FGFR2-mediated tumorigenesis and to develop targeted therapies.

2. Skeletal Disorders

Mutations in the FGFR2 gene have been linked to skeletal disorders such as achondroplasia and craniosynostosis. Recombinant Mouse FGFR2 Protein is used to study the role of FGFR2 in skeletal development and to develop potential treatments for these disorders.

3. Wound Healing

FGF signaling has been shown to play a crucial role in wound healing and tissue repair. Recombinant Mouse FGFR2 Protein has been used in studies to investigate the effects of FGFs on wound healing and to develop potential therapies for promoting tissue regeneration.

4. Drug Development

The dysregulation of FGFR2 signaling has been implicated in various diseases, making it a potential target for drug development. Recombinant Mouse FGFR2 Protein is used in drug discovery and development to screen for potential inhibitors or activators of FGFR2 signaling.

5. Biotechnology

Recombinant Mouse FGFR2 Protein is also used in biotechnology for the production of therapeutic proteins. It is commonly expressed in various cell lines to produce large quantities of recombinant protein for use in research and therapeutic applications.

Conclusion

Recombinant Mouse FGFR2 Protein is a crucial protein involved in cell signaling and regulation. Its structure, activity, and applications make it a valuable tool for studying various cellular processes and developing potential