Tebotelimab Biosimilar – Anti-PDCD1;LAG3 mAb – Research Grade

Description of Tebotelimab Biosimilar - Anti-PDCD1;LAG3 mAb - Research Grade

Tebotelimab Biosimilar – Anti-PDCD1,LAG3 mAb – Research Grade Introduction

Tebotelimab Biosimilar is a novel monoclonal antibody that targets two important immune checkpoint proteins, PDCD1 and LAG3. This research grade antibody has shown promising results in pre-clinical studies and has the potential to be a valuable tool in cancer immunotherapy.

Structure of Tebotelimab Biosimilar

Tebotelimab Biosimilar is a fully humanized IgG1 monoclonal antibody, meaning it is derived from human cells and has a similar structure to the antibodies naturally produced in our body. It has a molecular weight of approximately 150 kDa and consists of two heavy chains and two light chains, each with a variable region and a constant region.

The variable region of Tebotelimab Biosimilar is responsible for its specificity and binds to the target proteins, PDCD1 and LAG3. The constant region, on the other hand, plays a crucial role in the effector functions of the antibody, such as binding to immune cells and activating the immune response.

Mechanism of Action

Tebotelimab Biosimilar works by blocking the interaction between PDCD1 and its ligand, PD-L1, and also between LAG3 and its ligand, MHC class II molecules. These interactions are known to suppress the immune response and promote tumor growth. By inhibiting these interactions, Tebotelimab Biosimilar enhances the activity of T cells and other immune cells, leading to a stronger anti-tumor response.

In addition, Tebotelimab Biosimilar also has the ability to activate the immune system through its Fc region. This can lead to the recruitment of other immune cells, such as natural killer cells and macrophages, to the tumor site, further enhancing the anti-tumor response.

Applications of Tebotelimab Biosimilar

Tebotelimab Biosimilar has shown promising results in pre-clinical studies as a potential therapy for various types of cancer. It has been found to be particularly effective in tumors that overexpress PDCD1 and LAG3, such as melanoma, non-small cell lung cancer, and renal cell carcinoma.

Moreover, Tebotelimab Biosimilar can also be used as a research tool to study the role of PDCD1 and LAG3 in cancer and other diseases. Its ability to block the immune checkpoint proteins can provide valuable insights into the mechanisms of tumor immune evasion and help in the development of new therapies.

Conclusion

Tebotelimab Biosimilar is a promising research grade antibody that targets PDCD1 and LAG3, two important immune checkpoint proteins. Its unique mechanism of action and potential applications in cancer immunotherapy make it a valuable tool for both research and clinical use. Further studies and clinical trials are needed to fully understand the potential of Tebotelimab Biosimilar and its role in the treatment of cancer.

SDS-PAGE for Tebotelimab Biosimilar - Anti-PDCD1;LAG3 mAb

Tebotelimab Biosimilar - Anti-PDCD1;LAG3 mAb, on SDS-PAGE under non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.