Tenatumomab Biosimilar – Anti-TNC, HXB mAb – Research Grade

Description of Tenatumomab Biosimilar - Anti-TNC, HXB mAb - Research Grade

Introduction

Tenatumomab Biosimilar, also known as Anti-TNC, HXB mAb – Research Grade, is a monoclonal antibody that targets tenascin-C (TNC), a protein found in the extracellular matrix of various tissues. This biosimilar is a promising therapeutic agent for various diseases due to its unique structure, activity and potential applications.

Structure of Tenatumomab Biosimilar

Tenatumomab Biosimilar is a humanized monoclonal antibody, meaning it is derived from human cells and has been modified to reduce its immunogenicity. It is composed of two heavy chains and two light chains, each with a unique amino acid sequence. The heavy chains are linked to each other by disulfide bonds and are also connected to the light chains by disulfide bonds. This structure allows the antibody to bind specifically to TNC with high affinity.

Activity of Tenatumomab Biosimilar

TNC is a protein that is overexpressed in various diseases, including cancer, fibrosis, and autoimmune disorders. It plays a crucial role in cell adhesion, migration, and proliferation, making it a promising therapeutic target. Tenatumomab Biosimilar binds to TNC and inhibits its activity, thereby preventing its effects on cell behavior. This leads to a decrease in disease progression and symptoms.

Application of Tenatumomab Biosimilar

1.

Cancer treatment: TNC is highly expressed in various types of cancer, including breast, lung, and brain cancer. Tenatumomab Biosimilar has shown promising results in preclinical studies as a potential treatment for these cancers. It works by blocking the interaction between TNC and its receptors, which are involved in cancer cell growth and metastasis. This can potentially slow down tumor growth and prevent cancer spread.

2. Fibrosis treatment: TNC is also involved in the development of fibrosis, a condition characterized by excessive scarring in tissues. Tenatumomab Biosimilar has been shown to inhibit TNC-mediated fibrosis in animal models, making it a potential treatment for fibrotic diseases such as pulmonary fibrosis and liver fibrosis.

3.

Autoimmune disorders: TNC has been implicated in the development of various autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. Tenatumomab Biosimilar has shown promising results in preclinical studies as a potential treatment for these diseases. It works by blocking TNC-mediated inflammation and tissue damage.

4. Research tool: Tenatumomab Biosimilar is not only a potential therapeutic agent but also a valuable research tool. Its ability to specifically target TNC makes it useful for studying the role of TNC in various diseases and for developing new therapies.

Conclusion

Tenatumomab Biosimilar, also known as Anti-TNC, HXB mAb – Research Grade, is a humanized monoclonal antibody that specifically targets TNC. Its unique structure and activity make it a promising therapeutic agent for various diseases, including cancer, fibrosis, and autoimmune disorders. It also has potential applications as a research tool. Further research and clinical trials are needed to fully understand the potential of Tenatumomab Biosimilar in treating these diseases.

SDS-PAGE for Tenatumomab Biosimilar - Anti-TNC, HXB mAb

Tenatumomab Biosimilar - Anti-TNC, HXB mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.