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Microtubule-associated protein tau(MAPT)(1-441)

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Product nameMicrotubule-associated protein tau(MAPT)(1-441)
Uniprot IDP10636-8
Uniprot linkhttp://www.uniprot.org/uniprot/P10636-8
Expression systemProkaryotic expression
SequenceMGSHHHHHHSGMAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKST PTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKT KIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVV RTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIV YKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHG AEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Purity estimated>80% by SDS-PAGE
BufferPBS pH7.5
Delivery conditionDry Ice
Delivery lead time in business daysEurope: 5-7 working days
USA & Canada: 7-10 working days
Rest of the world: 5-12 working days
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
ApplicationsELISA,WB
Fragment TypeMet1-Leu441
Aliases /SynonymsNeurofibrillary tangle protein,Paired helical filament-tau,MAPTL, MTBT1, TAU
ReferencePX-P4601
NoteFor research use only

Description of Microtubule-associated protein tau(MAPT)(1-441)

General Information about Microtubule-associated protein tau (MAPT)

Microtubule-associated protein tau (MAPT) promotes microtubule assembly and stability, and may participate in the establishment and maintenance of neuronal polarity. The C-terminus binds to axon microtubules, while the N-terminus binds to the plasma membrane components, indicating that tau acts as a linker between the two. Axon polarity is predetermined by the TAU/MAPT positioning (in neuronal cells) in the cell body domain defined by the centrosome. The short isoform can make the cytoskeleton plastic, while the longer isoform can give priority to its stabilizing effect.

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