Recombinant Human CXCR7/ACKR3 Protein, N-His-SUMO

Description of Recombinant Human CXCR7/ACKR3 Protein, N-His-SUMO

Introduction to Recombinant Human CXCR7/ACKR3 Protein

Recombinant Human CXCR7/ACKR3 Protein, also known as C-X-C chemokine receptor type 7 or atypical chemokine receptor 3, is a G protein-coupled receptor (GPCR) that plays a crucial role in immune response and inflammation. This protein is encoded by the CXCR7 gene and is expressed in various tissues, including the brain, heart, and lungs. Recombinant Human CXCR7/ACKR3 Protein is produced through recombinant DNA technology, making it a valuable tool for research and therapeutic applications.

Structure of Recombinant Human CXCR7/ACKR3 Protein

Recombinant Human CXCR7/ACKR3 Protein is a transmembrane protein that belongs to the chemokine receptor family. It consists of 352 amino acids and has a molecular weight of approximately 40 kDa. The protein has seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. The extracellular region contains three N-glycosylation sites, which are important for protein stability and function.

The intracellular region of Recombinant Human CXCR7/ACKR3 Protein contains several conserved motifs, including a DRY motif, which is involved in G protein coupling, and a C-terminal PDZ-binding motif, which is responsible for protein-protein interactions. These structural features are essential for the proper functioning of the protein and can be targeted for drug development.

Activity of Recombinant Human CXCR7/ACKR3 Protein

Recombinant Human CXCR7/ACKR3 Protein is a chemokine receptor that binds to specific chemokines, small signaling proteins that regulate immune cell migration and activation. This protein has a high affinity for the chemokines CXCL11 and CXCL12, also known as stromal cell-derived factor 1 (SDF-1). Binding of these chemokines to Recombinant Human CXCR7/ACKR3 Protein leads to the activation of downstream signaling pathways, including the G protein-coupled pathway and the β-arrestin pathway.

Through these pathways, Recombinant Human CXCR7/ACKR3 Protein plays a crucial role in immune cell recruitment and activation, as well as in the regulation of cell proliferation, survival, and migration. It also has a role in angiogenesis, the formation of new blood vessels, and is involved in the development of the cardiovascular and nervous systems.

Applications of Recombinant Human CXCR7/ACKR3 Protein

The unique structure and activity of Recombinant Human CXCR7/ACKR3 Protein make it a valuable tool for various research and therapeutic applications. One of its primary uses is in the study of chemokine signaling and immune response. Recombinant Human CXCR7/ACKR3 Protein can be used to investigate the role of this receptor in different diseases, such as cancer, inflammation, and cardiovascular disorders.

Moreover, Recombinant Human CXCR7/ACKR3 Protein can be used as an antigen to generate specific antibodies for research and diagnostic purposes. These antibodies can be used to detect the expression and localization of Recombinant Human CXCR7/ACKR3 Protein in different tissues and cell types. They can also be used in immunohistochemistry and flow cytometry assays to analyze the function of this protein in various physiological and pathological conditions.

In addition to research applications, Recombinant Human CXCR7/ACKR3 Protein has potential therapeutic applications. Due to its involvement in various diseases, this protein has been identified as a potential target for drug development. Several studies have shown that targeting Recombinant Human CXCR7/ACKR3 Protein can have anti-inflammatory, anti-tumor, and neuroprotective effects. Therefore, this protein can be used as a